2004各专业指导性教学计划所涉与课程.docVIP

生物化学I（英） 课程号 周学时：3-0 学分： 3.0 英文名称：Biochemistry (A) I 一、教学目的与教学要求： 本课程将作为学生全面进行现代生物学其他课程学习的最重要基础课程，着重开展有关生物化学基础（生命的分子理论，细胞，生物分子，水）、分子构造和触媒作用（氨基酸，多肽和蛋白质，蛋白质的三级构造，蛋白质的功能，酶学，碳水化合物及糖生物学，核苷酸及核酸，脂肪，生物膜及运输，生物信号）、新陈代谢（生物能学原理，糖酵解，柠檬酸循环，脂肪酸氧化，氨基酸氧化及尿形成，氧化磷酸化及光化磷酸化，碳水化合物的合成，脂肪合成，氨基酸、核酸的合成）及信息通路（基因和染色体，DNA代谢，RNA代谢，蛋白质代谢，基因表达的调控，DNA重组技术）四个专题的讲授工作。课程结合经典的和最新的科学研究实例来阐述基本理论和概念，对生化实验技能具有重要的理论指导意义，并为学生今后从事生命科学相关的工作打下基础。 二、主要内容及学时分配（48学时）： The Molecular Logic of Life and Cell 3学时 The chemical unity of diverse living organism, Energy production and consumption in metabolism, Biological information transfer, Cells and tissues used in biochemical studies, Evolution and structures of prokaryotic and eukaryotic cells, Study of cellular components, Viruses. Biomolecues and Water 3学时 Chemical composition and bonding, Three-dimensional structure: configuration and conformation, Chemical reactivity, Macromolecules and their monomeric subunits, Prebiotic evolution, Weak interactions in aqueous systems, Ionization of water, weak acids, and Weak bases, Buffering against pH changes in biological systems, Water as a Reactant, The fitness of the aqueous environment for living organisms. Amino Acids, Peptides, and Proteins 6学时 Amino acids, Peptides and proteins, Working with proteins, The covalent structure of proteins. The Three-Dimentional Structure of Proteins 3学时 Overview of protein structure, Protein secondary structure, Protein tertiary and quaternary structures, Protein denaturation and folding. Protein Function 3学时 Reversible binding of a protein to a ligand: oxygen-binding proteins, Complementary interactions between proteins and ligands: the immune system and immunoglobulins, Protein interactions modulated by chemical energy: actin, myosin, and molecular motors. Enzymes