细胞疗法：治愈白血病的新希望.docVIP

Cell Therapy Shows Promise for Acute Type of Leukemia 细胞疗法：治愈白血病的新希望 A treatment that genetically alters a patient’s own immune cells to fight cancer has, for the first time, produced remissions in adults with an acute leukemia that is usually lethal, researchers are reporting. In one patient who was severely ill, all traces of leukemia vanished in eight days. 研究人员发布报告称，一种抗癌疗法首次缓解了急性白血病（通常是致命的）患者的病情，该疗法从基因上改变患者自身的免疫细胞，从而达到了抗击癌症的效果。一名重症患者在接受治疗后，其白血病症状在八天内完全消失。 “We had hoped, but couldn’t have predicted that the response would be so profound and rapid,” said Dr. Renier J. Brentjens, the first author of a new study of the therapy and a specialist in leukemia at Memorial Sloan-Kettering Cancer Center. “我们曾希望过，但从未料到患者对该疗法的反应会如此强烈和快速，”该疗法最新研究报告的第一作者、纪念斯隆-凯特琳癌症中心(Memorial Sloan-Kettering Cancer Center)的白血病专家雷尼尔·J·布伦蒂安斯(Renier J. Brentjens)说。 The treatment is experimental, has been used in only a small number of patients and did not work in all of them. But experts consider it a highly promising approach for a variety of malignancies, including other blood cancers and tumors in organs like the prostate gland. The new study, in five adults with acute leukemia, was published on Wednesday in the journal HYPERLINK /content/5/177/177ra38Science Translational Medicine. The treatment is similar to one that pulled a 7-year-old girl, HYPERLINK /2012/12/10/health/a-breakthrough-against-leukemia-using-altered-t-cells.html?pagewanted=allEmma Whitehead, from deaths door into remission nearly a year ago, and that has had astounding success in several HYPERLINK /2011/09/13/health/13gene.html?pagewanted=all_r=0adults with chronic leukemia in whom chemotherapy had failed. The treatment regimen that saved Emma and those adults was developed at the University of Pennsylvania. Related studies have also been done at the National Cancer Institute. 该疗法是实验性的，只被用于少数患者，而且不是对所有人都有效。但专家认为，该疗法对一些不同类型的恶性肿瘤来说是非常有前景的，包括其他类型的血癌以及器官肿瘤，如前列腺癌等。新研究的治疗对象是五名急性白血病成人患者，研究报告于周三发表在《科学转化医学》(HYPERLINK /content/5/177/