蛋白酪氨酸磷酸酶shp-2 与疾病的相关性研究 - 现代生物医学进展.pdf

现代生物医学进展 Progress in Modern Biomedicine Vol.15 NO.8 MAR.2015 1595 doi: 10.13241/ki.pmb.20 15.08.048 蛋白酪氨酸磷酸酶SHP-2 与疾病的相关性研究进展* 1 1 2 2 2 李 辉 王曙辰 李庆腊 宋玉文 刘晓谦 1 哈尔滨二四二医院神经外科 黑龙江哈尔滨 150066 ； 2 哈尔滨医科大学第四附属医院神经外科 黑龙江哈尔滨 150001 ） 摘要：蛋白酪氨酸磷酸酶家族由130 多种蛋白酪氨酸磷酸酶组成，它们和蛋白质酪氨酸激酶家族一起调控蛋白质中酪氨酸残基 SHP-2 的磷酸化以及去磷酸化的动态平衡，它们的活性直接决定细胞内蛋白质的磷酸化水平的高低。 是蛋白酪氨酸磷酸酶家族的 一员，在各种细胞和组织中均有广泛的表达，参与多个信号传导通路，介导细胞的生长、分化、迁移、粘附及凋亡等。SHP-2 的表达 异常会导致多种疾病的产生，但是相关综述较少，同时未见文献报道其在胶质瘤中的作用，因此本文简要介绍SHP-2 的结构、功 能、信号传导，并阐述了SHP-2 与常见疾病的关系。 ： ；疾病 关键词 蛋白酪氨酸磷酸酶；磷酸化；去磷酸化 ：Q591 Q75 ：A ：1673-6273 2015 08- 1595-03 中图分类号 ； 文献标识码 文章编号 （ ） The Development of Protein-tyrosine Phosphatase SHP-2 and Correlated Diseases* Protein-Tyrosine Phosphatase (PTPs) Family is constructed by more than 130 protein-tyrosine phosphatases, and could work together with protein-tyrosine kinase to modulate of phosphorylation and dephosphorylation balancing of tyrosine residue of proteins. Their activities affect the phosphorylation level of cellular proteins directly. SHP-2 is a member of PTPs Family, expressed extensively in cells and tissues. SHP-2 is involved in several cell signal pathways, as well as inducing cell proliferation, differentiation, migration, adhesion and apoptosis. The abnormality of SHP-2 would result in many disorders and disease, but the related review is is less. At the same time, the literature that reported its role in the glioma has not been found. So this article reviewed the structure, functions, cell signal transduction of SHP-2, as well