f-box蛋白家族在肿瘤发生中的作用 - 中国细胞生物学学报.pdf

网络出版时间：2015-07-31 11:11:15 网络出版地址：/kcms/detail/31.2035.Q1111.001.html 10.11844/cjcb.2015.08.0122 中国细胞生物学学报 Chinese Journal of Cell Biology 2015, 37(8): DOI: 10.11844/cj cb.2015.08.0122 F-box蛋白家族在肿瘤发生中的作用 * * 杨杨杨 李淑晶 伍会健 (大连理工大学生命科学与技术学院, 大连116024) 摘要 SCF(Skp 1-Cullin 1-F-box)复合体是一类泛素E3连接酶, F-box蛋白是构成SCF复合体的 亚基之一, 在泛素蛋白酶体途径(ubiquitin-proteasome pathway, UPP) 中介导SCF复合体特异性的识 别底物。SCF复合体通过降解特定底物在多种细胞进程中发挥关键调节作用, 如细胞增殖、细胞 周期进程、转录和细胞凋亡等。F-box蛋白参与的蛋白降解过程的失调会导致肿瘤的发生, 所以可 针对F-box蛋白进行癌症药物的设计。该文主要对F-box蛋白家族的结构特征和它们在肿瘤发生中 的功能进行了系统阐述, 为其将来作为药物靶点应用于癌症临床治疗提供理论基础。 关键词 F-box; SCF复合体; 泛素E3连接酶; 肿瘤发生 The Function of F-box Protein Family in Tumorigenesis Yang Yangyang, Li Shujing*, Wu Huijian* (School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China) Abstract SCF (Skp1-Cullin1-F-box) complex is a kind of E3 ubiquitin ligase. F-box proteins, one of the subunits that constitute the SCF complexes, mediate the substrate recognition specificity of SCF complex in the ubiquitin-proteasome pathway. Many cell processes, such as cell proliferation, cell-cycle progression, transcription and cell apoptosis, can be regulated by SCF complex through the degradation of specific substrates. The dysregulation of the protein degradation mediated by F-box proteins has been recognized to be closely related to tumorigenesis, so we can design t