鼻敏宁拆方对变应性鼻炎鼻黏膜一氧化氮合酶的干预作用.pdfVIP

166 Chin OtOrhinOlaryngOl J Integ Med 2008，Vo1．1 6．No．3 鼻敏宁拆方对变应性鼻炎鼻黏膜一氧化氮 合酶的干预作用 沈啸洪 【摘要】目的 进一步探时鼻敏宁组方中不同成分对鼻黏膜iNOS的调节作用。方法 制备变态反应性鼻炎豚鼠模型，将鼻 敏宁原方进行拆方，观察不同组分组成对模型动物鼻黏膜iNOS的影响。结果 祛风组分对iNOS有明显的干预作用，与对照组 相比差异有统计学意义(P0．01)；补气组分对iNOS无明显干预作用，与对照组相比差异无统计学意义(P0．05)。结论 鼻敏 宁原方的不同组分作用于变态反应性鼻炎的不同病理阶段。祛风组分主要在于减轻局部症状，补气组分主要存于维持体内免 疫平衡。作用模式体现了中药复方治疗疾病的综合性效应。 【关键词】鼻敏宁；药效学；组分；拆方研究 Experimental study on the pharmacological effect of Biminning in a way of various grouping components on iNOS in nasal mucosa with allergic rhinitis SHEN Xiaohong Dept．of Oto]aryngo]ogy,Nakai Hosplta]of Tianjin,TianyYn,300J00,China [Abstract]Objective To investigate the pharmacological effect of Biminning on iNOS in nasal mucosa with allergic rhinitis (AR)in a formula-resolving way based on an experimental study．Methods The pharmacological effect of Biminning on iNOS in nasal mucosa Was determined in a form ula—resolving way by immunohistochemical procedures among guinea pigs with experimentally induced allergic rhinitis．Results It was shown that the grouping components of herbals with the pharmacological effect of wind-dispelling held significant intervening effect on the activity ofiNOS in nasal mtlcosa with A＆significantly stronger than that ofcontrolling group(PO．0 1)，while there Was no such intervening effect for the grouping components ofherbals with the pharmacological effect ofQi-boosting on the activity ofiNOS in nasal mucosa ofanimals with AR with no significant difference when compared with that of controlling one(P)Ho．05)． Conclusions It Can be concluded from this study that different grouping components of herbals with various pharm acological effects in original fcrmula of Biminning may intervene with different stages of pathogenesis in