ASCO结肠癌进展.pptVIP

2009ASCO结肠癌进展 南昌大学第一附属医院肿瘤科 黎军和 分子指标预测Ⅱ期结肠癌高危复发 大型研究结果 Ceteximab疗效的预测 结肠癌辅助化疗终点 Oxaliplatin相关 synchronous stage IV colorectal cancer 化疗策略和方案的调整 其它 分子指标预测结肠癌高危复发及指导化疗 Abr4000 高通量 Abr4001MSI Abr 4002 Abr 4012 18q LOH Background: NSABP C-01/C-02 、CCF 、 C-04 、C-06 48 genes significantly associated with recurrence risk and 66 genes predictive of 5FU/LV benefit . Multivariate analysis yielded 18 genes (7 prognostic genes, 6 predictive genes, 5 reference genes) and separate prognostic recurrence score (RS) and predictive treatment score (TS) algorithms. Methods: Gene expression was quantit