超选择子宫动脉化疗栓塞治疗宫颈癌临床探究.docVIP

超选择子宫动脉化疗栓塞治疗宫颈癌临床探究【摘要】 目的 评价超选择子宫动脉化疗栓塞治疗宫颈癌的临床疗效及其安全性。方法 纳入宫颈癌患者58例,随机分为治疗组28例和对照组30例。治疗组予超选择子宫动脉化疗栓塞治疗,对照组予广泛性子宫切除加盆腔淋巴结清扫术,观察并记录其近期疗效和不良反应事件。结果 治疗组和对照组近期有效率分别为82.1%和90.0%,差异无统计学意义(P0.05)。治疗后评估治疗组5例NS患者行手术治疗,对照组3例NS患者后续以放射治疗。两组患者均无严重并发症发生。结论 超选择子宫动脉化疗栓塞治疗宫颈癌能减轻患者痛苦,提高患者生存质量,是一种安全有效的治疗方法。 【关键词】宫颈癌;化疗;栓塞 Clinical observation of super selective uterine artery infusion chemotherapy and embolization in treatment of cervical cancer WANG LI-ge.The ninth hospital of xian,Shanxi,710000,China 【Abstract】 Objective To evaluate the clinical efficacy and safety of super selective uterine artery infusion chemotherapy and embolization in treatment of cervical cancer.Methods 58 cases of cervical cancer confirmed by pathology were randomly divided into two groups 28 cases of treatment group and 30 cases of control group.Treatment group was treated by super selective uterine artery infusion chemotherapy and embolization.Control group was treated by therapy of extensive hysterectomy and pelvic lymph node dissection.Results The effective rate of treatment group and control groups were 82.1%and 90.0%,there was no significant difference between them(P0.05).Conclusion Superselective uterine arterial chemotherapy and embolization in treatment of cervical cancer which can reduce pain and improve quality of patients,is a safe and effective treatment. 【Key words】Cervical Cancer;Chemotherapy;Embolization 宫颈癌是妇科最常见的恶性肿瘤之一。经导管动脉内灌注化疗药物及超选择栓塞是近年来新发展的一种治疗方法,它能缩小肿块,减轻肿块与周围组织的浸润,降低其周围淋巴结的转移,减少术中出血,能使肿瘤的切除率明显提高,提高患者远期生存率及其生活质量,已成为治疗恶性肿瘤的重要方法。 1 对象和方法 1.1 对象 2003年3月至2009年7月在我院经病理活检确诊的宫颈癌患者78例,随机分为两组,治疗组28例,对照组30例。治疗组年龄33~57岁,平均48.3岁;根据1995年FIGO临床分期标准,Ⅰb2期1例、Ⅱa期9例、Ⅱb期13例、Ⅲa期2例、Ⅲb期2例、Ⅳ期1例;病理分型:宫颈鳞癌16例,宫颈腺癌11例、小细胞癌1例;分化程度:高分化3例,中分化23例,低分化2例。对照组年龄31~79岁,平均51.7岁;根据1995年FIGO临床分期标准,Ⅰb2期2例、Ⅱa期8例、Ⅱb期12例、Ⅲa期4例、Ⅲb期3例、Ⅳ期1例。病理分型:宫颈鳞癌17例,宫颈腺癌11例、小细胞癌2例。分化程度:高分化5例,中分化22例,低分化3例。所有患者均经宫颈活检,病理检查确诊。所有患者血常规、肝肾功能及心电图正常,均签署知情同意。 1.2 方法 治疗组采用Seldinger技术从一侧股动脉穿刺插管至对侧髂内动脉,静脉注射碘造影剂,造影显示病变部位及血供动脉后,