医工所演讲讯息.PDFVIP

醫工所演講訊息 講題： Engineering on the Straight and Narrow: Musculoskeletal Tissue Engineering with Dynamic Nanofibrous Scaffolds 講者： Dr. Robert L. Mauck Assistant Professor of Orthopaedic Surgery and Bioengineering University of Pennsylvania 時間： 8 月9 日周一上午 10:30 地點： 台大校總區醫工所會議室 展書樓506 室 摘要 Engineering fibrous tissues of the musculoskeletal system represents a considerable challenge due to the complex architecture and mechanical properties of the component structures. Natural healing in these dense tissues is limited as a result of the mechanically challenging environment of the damaged tissue and the hypo-cellularity and avascular nature of the extracellular matrix. When healing does occur, the ordered structure of the native tissue is replaced with a disorganized fibrous scar with inferior mechanical properties, engendering sites that are prone to re-injury. To overcome these limitations, we and others have adopted a structurally-motivated tissue engineering approach based on organized nanofibrous assemblies. These scaffolds are composed of ultra-fine biodegradable and biologic fibers that can be fabricated in such a way as to recreate the structural anisotropy typical of fiber-reinforced tissues. This ‘straight and narrow’ topography not only provides tailored mechanical properties, but also serves as a 3D micro-pattern for directed tissue formation. This talk will describe the underlying technology of nanofiber production, several newly developed fabrication strategies aimed at instilling dynamic and multi-functional characteristics, and the mechanical evaluation and theoretical modeling of these scaffolds as it relates to native tissue structure and function. Several case examples in which these principles have been