甘草不同粒径粉末的粉体特性和体外溶出试验研究-南方医科大学学报.PDF

2010;30(5) 南方医科大学学报(JSouthMedUniv) 窑1079窑 甘草不同粒径粉末的粉体特性和体外溶出实验研究 刘 莉袁吴柳萍袁刘 强渊南方医科大学中医药学院袁广东广州510515冤 摘要院目的 比较甘草不同粒径粉末的粉体学特征和体外溶出度袁对粒径大小与甘草黄酮溶出特点的关系进行研究袁探 索超微粉碎技术在中药甘草中的应用遥 方法通过光学显微镜观察不同粒径粉末的粉末形貌和细胞特征袁 并对粉体学 参数休止角和粒径分布进行测定曰采用紫外分光光度法测定甘草总黄酮的含量袁采用高效液相色谱法测定有效成分甘 草苷的含量曰用恒温搅拌溶出法对4种粉末中甘草总黄酮和甘草苷的溶出特点进行研究遥结果甘草超微粉和普通粉的 粉体学特征尧表面形态差异较大曰甘草超微粉中甘草总黄酮和甘草苷溶出的速度与溶出量要高于普通粉遥 结论超微粉 碎后有助于甘草饮片中甘草黄酮的溶出袁粉碎粒度对甘草黄酮的溶出有显著影响遥微粉化能促进甘草黄酮的充分利用遥 关键词院甘草曰甘草黄酮曰甘草苷曰超微粉碎 中图分类号院R285.5 文献标识码院 文章编号院1673-4254渊2010冤05-1079-03 PharmaceuticalcharacteristicsofGlycyrrhizae radixmicropowder LIULi,WULiu-ping,LIUQiang CollegeofTraditionalChineseMedicine,SouthernMedicalUniversity,Guangzhou510515,China Abstract: Objective To characterize the micromeritic properties and in vitro dissolution of common powder and micropowderof Glycyrrhizaeradixandexploretheapplicationofmicronizationtechniqueinpreparationofthedrug. Methods Themorphologicalandcellularcharacteristicsofthe4powdersof Glycyrrhizae radixwereexaminedmicroscopically, and their angleofrepose and size distribution were measured. The content oflicoflavone and liquirtin in the powders were determinedbyhigh-performanceliquidchromatographyandultravioletspectrophotometry,respectively.Thedissolutionrate oftheactiveingredientsinthemicropowderandcommonpowderwasstudiedbyconstanttemperaturemixingdissolution method. Results Significantdifferenceswereobservedbetweencommonpowderandmicropowderinparticlecharacteristics andsurfacemorphology.Thedissolutionratesandtheconcentrationsofthecorrespondingingredientsinthemicropowderwere higherthan thecommon powder. Conclusion Micronization is helpful forbetter utilization of the active components in Glycyrrhizaeradix. Keywords: Glycyrrhizaeradix;licoflavone;liquirtin;micronization 超微粉碎技术是近年来发展起来的一项高新技 实验依据遥 术袁尤其应用于中药研究中显露出特有的优势遥 一般 情况下植物药有效成分需通过细胞壁