miR-126在心血管疾病中的研究进展.PDF

²1800 ² 中华临床医师杂志( 电子版)2016 年6 月第10 卷第 12 期 Chin J Clinicians(Electronic Edition),June 15,2016,Vol.10,No.12 ²综述² miR- 126 在心血管疾病中的研究进展 1 2 吴雪纯 贾永平 【摘要】 微小核糖核酸（miRNAs ）是真核生物中一类内源性的非编码RNA，通过和靶基因 mRNA 碱基配对引导沉默复合体（RISC ）降解mRNA 或阻碍其翻译，具有组织特异性和时序性， 参与细胞生长、发育、增殖、分化等多个生命过程。miRNA- 126 是一种内皮特异性 miRNA，在人 类的心脏和内皮系统中高度表达。研究表明，miRNA- 126 参与心血管疾病发生、发展的多个过程， 对诊断疾病和评价预后起着重要的作用，本文将对miRNA- 126 在动脉粥样硬化、冠心病、心力衰竭、 糖尿病等疾病中的研究进展进行综述。 【关键词】 微RNAs； 动脉粥样硬化； 冠心病； 心力衰竭； 糖尿病 1 2 1 Research progress of miR-126 in cardiovascular diseases Wu Xuechun , Jia Yongping . The First Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China; 2Department of Cardiology, the First Hospital of Shanxi Medical University, Taiyuan 030001, China Corresponding author: Jia Yongping, Email:849782305@ 【Abstract 】MicroRNAs (miRNAs) is a kind of endogenous non-coding RNA in eukaryotes, which possesses the organization specificity and scheduling in cell growth, development, proliferation, differentiation and other life processes, through the guidance of base pairing and target gene mRNA silence complex (RISC) degradation of mRNA or hinder its translation. miRNA-126 is a kind of endothelial specific miRNA, which is highly expressed in the human heart and in the endothelial system. Studies have shown that miR-126 participates in the occurrence and development of cardiovascular disease process, and has important role for diagnosis and estimating prognosis. Here we reviewed the progress of miRNA-126 in the atherosclerosis, coronary heart disease, heart failure and diabete. 【Key words 】 MicroRNAs; Atherosclerosis; Coronary disease; Heart failure; Diabetes mellitus 微小核糖核酸（microRNAs ，mi