拉米夫定治疗慢性乙型重型肝炎疗效观察.doc

拉米夫定治疗慢性乙型重型肝炎疗效观察【摘要】目的 观察拉米夫定治疗慢性乙型重型肝炎的疗效。方法 40例慢性乙型重型肝炎患者随机将28例分为治疗组和12例为对照组，两组均给予基础治疗，治疗组加用拉米夫定100mg，口服，1次/d。每1周检测肝功能、凝血酶原时间，每4周检测血清HBV-DNA。结果 加用拉米夫定的治疗组与对照组比较血清生化各项指标下降明显，差异有显著性（P0.05），治疗后两组各项指标比较差异有显著性（P 本组资料显示,加用拉米夫定治疗慢性乙型重型肝炎可改善肝功能，缓解病情，降低病死率。但与其他药物的配伍可否再进一步提高疗效，有待进一步研究证明。 参考文献 [1] Tiwari S, Vyas SP. Novel approaches to oral immunization for hepatitis B[J].Curr Infect Dis Rep. 2011,13(1):4-12. [2] Shin SR, Koh KC, Gwak GY,et al. A low viral load predicts a higher initial virologic response to adefovir in patients with Lamivudine-resistant chronic hepatitis B[J].Gut Liver. 2010 ,4(4):530-6. [3] 中华医学会传染病与寄生虫病学分会和肝病学分会. 病毒性肝炎防治方案[J]. 中华肝脏病杂志,2000 ,6 :3242329. [4] Kawagishi N, Takeda I, Miyagi S, et al. Nucleoside analogue therapy following one-year course of hepatitis B immunoglobulin in preventing hepatitis B virus reactivation after living donor liver transplantation[J].Tohoku J Exp Med. 2010,222(4):275-9. [5] Roussos A, Koilakou S, Kalafatas I, et al. Lamivudine treatment for acute severe hepatitis B: report of a case and review of the literature[J].Acta Gastroenterol Belg. 2008 ,71(1):30-2. [6] Bellini C, Keiser O, Chave JP, et al.Liver enzyme elevation after lamivudine withdrawal in HIV-hepatitis B virus co-infected patients: the Swiss HIV Cohort Study[J].HIV Med. 2009 ,10(1):12-8. [7] Deli? D, Nesi? Z, Prostran M, et al.Treatment of subacute hepatitis B with lamivudine: a pilot study in Serbia[J].Vojnosanit Pregl. 2009 ,66(3):199-202. [8] Sperl J, Franková S, Spicák J.Viral hepatitis in immunosuppressed patients[J].Klin Mikrobiol Infekc Lek. 2010,16(4):120-3. [9]Chen CY, Ni YH, Chen HL, et al.Lamivudine treatment in infantile fulminant hepatitis B[J].Pediatr Int. 2010 ,52(4):672-4. [10] Akima T, Tamano M, Yamagishi H, et al.Surgical treatment of HCC in a patient with lamivudine-resistant hepatitis B cirrhosis with adefovir dipivoxil[J].World J Hepatol. 2010 ,2(8):318-21. [10] Ikeda F, Kobashi H, Yamamoto K.T