肾综合征出血热患者血浆肾素-血管紧张素Ⅱ及前列环素水平及临床意义.docVIP

肾综合征出血热患者血浆肾素\血管紧张素Ⅱ及前列环素水平及临床意义[摘要]目的探讨肾综合征出血热(HFRS)患者血浆肾素(PRA)、血管紧张素Ⅱ(ATⅡ)和前列环素(PGI2)含量与患者病情的关系。方法采用放射免疫法测定PRA、ATⅡ含量,饱和竞争放射免疫分析法测定PGI2含量,日本CL-7200全自动生化分析仪检测血清尿素氮(BUN)、肌酐(Cr)水平。结果 HFRS患者各病期(或病型)血浆PRA、ATⅡ及血清 BUN、Cr含量显著高于对照组,而血浆PGI2水平显著低于对照组,其中以少尿期、重型及危重型患者指标变化更为明显。结论 HFRS血浆PRA、ATⅡ、PGI2及血清BUN、Cr等指标与患者病情密切相关,可作为判断HFRS分期及严重程度的指标。 [关键词] 肾综合征出血热; 血浆肾素; 血管紧张素Ⅱ; 前列环素 [中图分类号] R512.8 [文献标识码] A [文章编号] 1673-9701(2010)05-53-02 Plasma Renin,Angiotensin Ⅱ and Prostacyclin Levels in Hemorrhagic Fever with Renal Syndrome and Their Clinical Significance CHEN Yang HAN Yonghui XU Guijuan Shenyang Municipal Sixth People’s Hospital,Shenyang 110006,China [Abstract]Objective To investigate the dynamic changes of the plasma rennin,angiotensin Ⅱand prostacyclin as well as the serum urea nitrogen and creatinine levels in hemorrhagic fever with renal syndrome and to explore their correlation with severity of the disease. Methods The levels of plasma rennin and angiotensin Ⅱ were determined by using radioimmunoassay and the prostacyclin level was determined by saturated competitive radioimmunoassay. The levels of serum urea nitrogen and creatinine were determined with Japan CL-7200 automatic biochemical analyzer. ResultsThe plasma rennin and angiotensin Ⅱlevels and the serum urea nitrogen and creatinine levels were significantly higher and the prostacyclin level was significantly lower in hemorrhagic fever with renal syndrome,especially more evident changes in the indicators in oliguria period and severe and critical patients,than those in the control group. Conclusion Such indicators as the plasma rennin,angiotensin Ⅱand prostacyclin as well as the serum urea nitrogen and creatinine in hemorrhagic fever with renal syndrome are closely correlated with the severity of the disease and can be used as judgment of the staging and severity of the disease. [Key words]Hemorrhagic fever with renal syndrome; Plasma rennin; Angiotensin Ⅱ; Prostacyclin 肾综合征出血热(Hemorrhagic fever wit