中药戒毒药的研究进展.PDFVIP

中草药 =q==e=a 第 T 卷 第 P 期 =OMNS 年 O 月 ·RNV · 中药戒毒药的研究进展 夏 宇，侯小龙，方建国，王文清，施春阳* 华中科技大学同济医学院附属同济医院 药学部，湖北 武汉 430030 摘 要：吸毒不仅对人类自身健康具有巨大的伤害，也严重威胁着家庭和社会的和谐稳定。中药戒毒历史悠久，具有无成瘾 性、多靶点作用等化学药无法比拟的优势，成为国内外的研究热点。在日趋完善的中医戒毒理论指导下，目前已有 9 种中药 戒毒药上市。临床实践证明，中药戒毒药在稽延性症状的治疗、防复吸等方面疗效确切，且无成瘾性。综述近年来中药戒毒 有效成分和戒毒机制等方面的研究进展，为研发更为安全有效的中药戒毒药提供一定的参考。 关键词：中药；戒毒；海洛因依赖；稽延性症状；复吸 中图分类号：R285 文献标志码：A 文章编号：0253 - 2670(2016)03 - 0519 - 09 alfW 10.7501/j.issn.0253-2670.2016.03.027 o === XIA Yu, HOU Xiao-long, FANG Jian-guo, WANG Wen-qing, SHI Chun-yang Department of Pharmacy, Tongji Hospital Affiliated with Tongji Medical College, Huazhong University of Science and Techonology, Wuhan 430030, China W Drug addiction is not only destructive to human’s own health ，but also a serious threat to the harmony and stability of family and society. Getting rid of drug addiction through Chinese materia medica (CMM) has a long history, with the advantages (e.g. no addiction and multi-targets effects) to which Western medicine can not match, rendering it a hotspot in domestic and international research. The rehabilitation medicines of nine herbal drugs have been developed under the guidance of the ever improving detoxification theory of traditional Chinese medicine (TCM). Clinical practice has proved that CMM detoxification agents have the remarkable curative effect in the treatment of protracted withdrawal syndrome, relapse prevention, etc, and have no addiction. In this paper, author reviews the progress in the studies on the active detoxification ingredients of single Chinese herb and therapeutic mechanism of CMM detoxification agents for the purpose of providing the certain references for the development of safer and more efficient detoxification medicines of CMM. h W Chinese materia medica; detoxification; heroine dependence;