皮肤毛囊发育的转录组研究进展.PDF

Hereditas (Beijing) 2015 年6 月, 37(6): 528 ―534 综 述 皮肤毛囊发育的转录组研究进展 江玮，范一星，乔贤，张燕军，刘志红，赵艳红，王瑞军，王志新，张文广， 苏蕊，李金泉 内蒙古农业大学动物科学学院，动物遗传育种与繁殖内蒙古自治区实验室，呼和浩特 010018 摘要:近年来，转录组测序技术在动物重要经济性状受复杂基因网络的调控研究领域取得了显著的成果。作为 哺乳动物皮肤的衍生物，毛囊是唯一具有高度自我更新能力、独特的可再生器官，毛囊细胞经增殖分化最终形 成毛发。已有的研究表明，诸多生长因子及其受体作为体内分泌协调基因的重要因素，对毛发的生长发育起着 重要的调控作用。文章综述了近年来转录组测序技术在人、小鼠及羊等生物的皮肤毛囊发育和再生过程中基因 调控方式的研究进展，旨在为今后人工干扰绒毛周期生长发育和分子育种提供理论依据, 同时也为皮肤毛囊相 关疾病的临床治疗提供新思路。 关键词:毛囊；转录组；人；小鼠；羊 The transcriptome research progresses of skin hair follicle development Wei Jiang, Yixing Fan, Xian Qiao, Yanjun Zhang, Zhihong Liu, Yanhong Zhao, Ruijun Wang, Zhixin Wang, Wenguang Zhang, Rui Su, Jinquan Li Inner Mongolia Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Agricultural University, Hohhot 010018, China Abstract: Recently, transcriptome sequencing technology has achieved significant progresses in gene network regulation of important economic traits in animals. As the derivative of mammalian skin, hair follicle is capable of self-renew. Its proliferation and differentiation result in hair formation. Researches have revealed that many growth factors and receptors coordinate genes and environment, as well as play an extremely important role during hair growth. In this review, we summarize the progresses that transcriptome sequencing technologies have achieved in researches of hair follicle development and renegeration in a variety of species, such as humans, mice, goats. We aim to provide theoretical mechanisms for the artificial interference of villus growth cycle, and new ideas for therapeutic treatment of skin hair follicle- related diseases. Keywords: hair follicle; transcriptome; human; mice; goat 收稿日期: 2014−12−12 ; 修回日期: 2015−04−15 基金项目: 国家高技术研究发展计划项目(863 计划)(编号：2013AA102506) ，国家自然科学基金项目(编号