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薏苡仁油软胶囊对移植于裸鼠的人体前列腺肿瘤 PC-3M 的抑制作用 1 2 2 2 2* 蔡烈涛 ，尹蓓珮 ，刘畅 ，陆宏祺 ，李炳生 (1. 310018 2. 200437) 浙江康莱特集团有限公司，杭州 ； 上海医药工业研究院，上海 摘要：目的 研究薏苡仁油软胶囊对移植于裸鼠的人体前列腺肿瘤 PC-3M 的抑制作用。方法 制备移植于裸鼠的人体前列 腺肿瘤 PC-3M 模型，动态观察和测量肿瘤大小及荷瘤鼠体重，按金氏公式计算肿瘤抑制率及相对肿瘤增长率。结果 单用 薏苡仁油软胶囊三个剂量组对移植于裸鼠的人体前列腺肿瘤 PC-3M 抑瘤率分别为 44.50% 、40.52%、28.44% ，合并泰素抑 瘤率分别为 58.18%、59.36%、54.92%。结论 单用薏苡仁油软胶囊三个剂量组对移植于裸鼠的人体前列腺肿瘤有一定抑制 作者简介：蔡烈涛，男，主管中药师 Tel: (0571E-mail: *通信作者：李炳生，男，研究员 Tel: (021)5514600 E-mail: libs@ ·1080 · Chin JMAP, 2010 December, Vol.27 No.12 中国现代应用药学2010 年 12 月第 27 卷第 12 期 作用；合并泰素明显具有相加作用。 关键词：薏苡仁油软胶囊；裸鼠；前列腺肿瘤 PC-3M ；金氏公式 中图分类号：R285.5 文献标志码：A 文章编号：1007-7693(2010)11-1080-04 The Inhibiting Effect of Coix Seed Oil Soft Capsule on Human Prostate Tumor PC-3M Grafted in Nude Mice 1 2 2 2 2* CAI Lietao , YIN Beipei , LIU Chang , LU Hongqi , LI Bingsheng (1.Zhejiang Kanglaite Group Co., Ltd., Hangzhou 310018, China；2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437, China) ABSTRACT: OBJECTIVE To study the inhibiting effect of coix seed oil soft capsule on human prostate tumor PC-3M grafted in nude mice. METHODS Establish the module of human prostate tumor PC-3M grafted in nude mice ，dynamically observe and measure the tumor size and body weight of mice bearing tumors. And calculate tumor inhibition rates and relative growth rates with King formula. RESULTS The inhibition rates of three dose groups of coix seed oil soft capsule alone were 44.50%,40.52% and 28.44% respectively ，the inhibition rates of chemotherapy(Taxol) combination groups were 58.18%,59.36% and 54.92% respectively. CONCLUSION Coix seed oil soft capsule used alone has certain inhibition effect on human prostate tumor grafted in nude mice. The combinatio