An EvidenceBased Review of the Use of a （一个EvidenceBased审查使用）.pdf

An Evidence-Based Review of the Use of a Combat Gauze (QuikClot) for Hemorrhage Control Brian T. Gegel, CRNA, DNAP Paul N. Austin, CRNA, PhD Arthur “Don” Johnson, RN, PhD, Col(ret), USAFR, NC Trauma is a leading cause of morbidity and mortal- of lower-level human and animal research. It did not ity. Uncontrolled hemorrhage related to the traumatic conclusively demonstrate that this combat gauze is an event is often the major cause of complications and effective hemostatic agent for use in trauma patients, death. The use of hemostatic agents may be one of the but the results are promising in supporting its use. easiest and most effective methods of treating hem- The evidence does not describe serious side effects, orrhage. The US military recommends a hemostatic exothermic reaction, and thromboemboli formation combat gauze (QuikClot Combat Gauze) as the first-line associated with other hemostatic agents. Further inves- hemostatic agent for use in treatment of severe hemor- tigation to determine the effectiveness of hemostatic rhage. This review provides essential information for agents, specifically QuikClot Combat Gauze, in the evidence-based use of this agent. The PICO (patient, management of trauma casualties in the prehospital intervention, comparison, outcome) question guid- setting is required. These should include large-scale, ing this search for evidence was: Is QuikClot Combat multicenter, prehospital randomized controlled trials. Gauze, a hemostatic agent, effective and safe in con- trolling hemorrhage in trauma patients in the prehospi- Keywords: Combat ga