COMPARISON OF N O ANTICOAGULANTS AND （比较N O抗凝血剂和）.pdfVIP

COMPARISON OF NEW ORAL ANTICOAGULANTS AND FREQUENTLY- ASKED QUESTIONS FROM PATIENTS AND PHYSICIANS TARGET AUDIENCE: All Canadian health care professionals. OBJECTIVES: •• To provide a comparison of the new oral anticoagulants currently available in Canada. •• •• To address frequently-asked questions from patients and physicians regarding the new oral •• anticoagulants. ABBREVIATIONS: AF atrial fibrillation aPTT activated partial thromboplastin time CrCl creatinine clearance INR international normalized ratio NOAC new oral anticoagulant (dabigatran, rivaroxaban, apixaban) NSAID non-steroidal anti-inflammatory drug NSTEMI Non-ST elevation myocardial infarction PT prothrombin time STEMI ST elevation myocardial infarction TCT thrombin clotting time VTE venous thromboembolism FOR PATIENTS : PRACTICAL AND LIFESTYLE ISSUES What if I miss doses of a new oral anticoagulant (NOAC) for 1 or 2 days? Do not ‘double the dose’ to make up for the missed dose(s). If you have an irregular heartbeat (atrial fibrillation) and 1 or 2 days doses of these drugs are missed, simply continue at the usual dose starting with the next scheduled dose. However, if you are taking rivaroxaban twice daily during the first 3 weeks after a blood clot in the leg or lungs, you should take a missed morning dose as soon as possible and make sure you take 2 of the 15 mg tablets that day. Can I place my NOAC medication in a dose e? Rivaroxaban and apixaban, which come in a pill form, can be placed in a dosette. This is not the case with dabigatran, which is a capsule. Dabigatran needs to be kept in the medication packaging until it is taken, but it can be placed in its blister pack within the dosette. © 2013 Thrombosis Canada.