Cosmetic benefits of astaxanthin on humans （整容的好处虾青素对人类）.pdfVIP

Vol. 59, No 1/2012 43–47 on-line at: www.actabp.pl Regular paper Cosmetic benefits of astaxanthin on humans subjects* Kumi Tominaga, Nobuko Hongo, Mariko Karato and Eiji Yamashita* Fuji Chemical Industry Co. Ltd., Kamiichi, Toyama, Japan Two human clinical studies were performed. One dermatological actions, suppression of hyper-pigmenta- was an open-label non-controlled study involving 30 tion (Yamashita, 1995) and inhibitions of melanin syn- healthy female subjects for 8 weeks. Significant im- thesis and photoaging (Arakane, 2002) have been report- provements were observed by combining 6 mg per ed. We have previously reported three clinical studies to day oral supplementation and 2 ml (78.9 μM solution) evaluate either topical or oral supplementation effects of per day topical application of astaxanthin. Astaxanthin astaxanthin derived from the microalgae H. pluvialis. The derived from the microalgae, Haematococcus pluvia- first as a small pilot study was the repeated topical ap- lis showed improvements in skin wrinkle (crow’s feet plication test of a cream containing not only astaxanthin at week-8), age spot size (cheek at week-8), elasticity but other active ingredients and effective base materi- (crow’s feet at week-8), skin texture (cheek