达比加群在冠心病心房颤动射频导管消融术后抗凝治疗的应用.PDF

达比加群在冠心病心房颤动射频导管消融术后抗凝治疗 Comment [A]: 英文题名请用大写黑体 。 的应用 谢 华 （湖北医药学院附属襄阳医院湖北省襄阳市第一人民医院心血管内科 襄阳 441000 ） 摘要 目的：观察达比加群在冠心病心房颤动患者行射频导管消融术后抗凝治疗的应用。方法： 选取2012年12月至2015 年12月收治的102例冠心病心房颤动患者作为研究对象，并采取随机分组的方式将所有研究 对象分为观察组及对照组，观察组患者采取术后达比加群抗凝治疗，对照组患者采取术后 华法林抗凝治疗，记录所有患者的年龄、性别以及肝肾功能指标等一般资料，治疗1年后对 患者进行定期随访，观察患者治疗的安全性及有效性并对比其临床治疗效果及出血风险。 结果：两组患者的一般资料及临床指标比较差异无统计学意义(P0.05) ；观察组患者的血栓栓塞发生率（3.92% ）与对照组患者血栓栓塞发生率（5.88% ）比较，差异具有统计学意义 (P0.05) 。观察组患者出现出血并发症发生率（6.8% ）与对照组患者出现出血并发症的发生率（8.9 % ）比较，差异无统计学意义 (P0.05) 。结论：冠心病心房颤动患者行射频导管消融术后应用达比加群进行抗凝治疗可达到明显 治疗效果且无需检测INR (International Normalized Ratio) 值，方便有效，值得在临床推广。 关键词 达比加群；华法林；抗凝治疗；射频导管消融术；疗效；INR值 中图分类号： 文献标志码：A 文章编号： To observe the clinical effect of anticoagulant therapy group associated with radiofrequency catheter ablation of atrial fibrillation after coronary heart disease Xie Hua （Hubei Hospital Affiliated to Xiangyang Medical College Hubei first peoples Hospital of Xiangyang province Xiangyang 441000, China) [Abstract] Objective: To observe and analysis of coronary heart disease with atrial fibrillation patients underwent radiofrequency catheter ablation after application of Darby and group of the efficacy of anticoagulation therapy, to provide a reference and guidance for the clinical work. Methods: a total of December 2012 ~ 2015 12 month period after treated in our hospital from 102 cases of coronary heart disease with atrial fibrillation patients as the research object and take were randomly divided into two groups, all subjects were divided into the observation group and the control group were patients take peri operative Darby and anticoag