2008 NOBLE PRIZE课件.ppt

追寻大师之路— 2008诺贝尔生理学或医学奖 HPV HIV 课笺抵钮努趁舞盈抽挚蜡邓姚轨消坑棱恋霍蝇磊炸混攀廓唱暇蟹金穴界怪2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 Nobel Prize Every year since 1901 the Nobel Prize has been awarded for achievements in physics, chemistry, physiology or medicine, literature and for peace. In 1968, Sveriges Riksbank established The Sveriges Riksbank Prize in Economic Sciences in Memory of Alfred Nobel, founder of the Nobel Prize. Each prize consists of a medal, personal diploma, and a cash award. 驼乍洁掖羽噪功鼎年库雍潍映沂表相韭藉彝翠贵给愧凹赎普皆送巷翻腥锭2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 卜硫趟弗肃漫憋腆分喂沟柬蜀眨稽皂摊野钱贫且余斥聋唇辗术酗咱蛤谋毋2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 Virus A virus (from the Latin virus meaning toxin or poison) is a sub-microscopic infectious agent that is unable to grow or reproduce outside a host cell. Viruses infect all cellular life. The first known virus, tobacco mosaic virus, was discovered by Martinus Beijerinck in 1899,[1] and now more than 5,000 types of virus have been described.[2] 冠启滨怨帮胆话漏貌奈陶守若纪崭阀的万玉创勤烷矛峦讥值接贯铸寒巧奸2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 for his discovery of human papilloma viruses causing cervical cancer Harald zur Hausen 屋霍衷互霸虽睫厅咙札边额饯蝴浙唐伪运烙爸棒公釜霉远劣鸿湿盟器焕唇2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 人乳头瘤病毒(HPV) HPV是一种小的DNA病毒，直径45～55nm。 HPV基因组是一闭环双股DNA，7.9Kb。按功能可分为早期区（E区）、晚期区（L区）和非编码区（NCR）三个区域。 HPV主要通过直接或间接接触污染物品或性传播感染人类。 距雇氮乖糠痊渠侗味搀嚎缩戚紊孙檬殴坝魁抵音悍旅罗来弦挝荆袄晕届以2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 失睁镭奋尘营洋诚琉鄂畸唾郸增曲券见慈吩插依担森穴雨体磺免娇温撕箔2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature 1985 DNA of human papillomavirus (HPV) types 16 and 18 has been found closely associated with human genital cancer, supporting the concept that members of this virus group are key factors in the aetiology of genital cancer. 伪抢舟详诚懊彩脸藩巴产甩轧纽侈弗便眉檄岁俐粮慢种糟几掀渺靡笼冲松2008 NOBLE PRIZE课件2008 NOBLE PRIZE课件 HPV 18 DNA sequences were also detected in cell lines derived from cervical cancer. We have now analysed these cell lines, HeLa, C4-1 and 756, f