二甲双胍对2型糖尿病病人造影剂肾病的影响_李耀静.pdfVIP

47 　5 Vol.47, No.5 2011 10 ACTA ACADEMIAE MEDICINAE QINGDAO UNIVERSITA TIS October　2011 二甲双胍对2 型糖尿病病人造影剂肾病的影响 ,, (, 　2 003) [] 　　2 (T2DM)。　 T2DM , , 。 3 d、1 。　(P0.05)。 、、(GFR)(P0.05)。GFR 30 ～90 mL/ min , 3 d GFR (t=2.485, P0.05)。　 T2DM 。 [] 　;, 2 ;; [] 　R578.1　　[]　A 　　[] 　1 72-4488(2011)05-0434-03 THE EFFECTS OF METFORMIN ON CONTRAST MEDIA NEPHROPATHY IN PATIENTS WITH TYPE 2 DIABETES MELLITU S LI YAO-J I N G, WA N G J I N G, GAO YAN -YA N 　(Department of Endocrinology, The Affiliated H ospital of Qingdao University M edical College, Qingdao 2 003, China) [ABSTRA CT] 　Obj ective　T o evaluate the influence of metformin on renal function in patients w ith Type 2 diabetes mellitu s (T2DM )before angiog raphy.　Methods 　A retrospective review w as done for 100 T2DM patients underw ent angiography in De- partment of cardiology.T hey w ere equally divided into metformin g roup and non-metformin group based on w hether o r not using m etformin before angiography.The renal function and uric acid w ere measured before, and three days and one year after angiogra- phy.　Res ult s 　The difference of the incidence of contrast-induced nephropathy betw een the two groups w as not significant (P 0.05).T he levels of serum creatinine and glomerular filtration rate (GFR)had no significant changes w ithin each g roup before and after angiog raphy, and betw een the tw o groups as well.When GFR ranged 30-90 mL ·min-1, GFR significantly declinedin met- formin group three days after angiography (t=2.485,P0.05).　Concl usion　For T2DM patients w ithout com plicating renal failure, or those do not discontinue metfo rmin due to em ergency, angiog raphy is relatively safe. [KEY WORDS] 　metformin;diabetes mellitus, ty pe 2;nephropathy;