从2型糖尿病的发病机制谈糖尿病治疗的新策略_刘佩文.pdfVIP

: ()2008 2 29 2 351 从2 型糖尿病的发病机制 谈糖尿病治疗的新策略 ① ① ＊ 刘佩文 　余学锋 :2 型糖尿病的发病机制主要为胰岛素抵抗与胰岛β 细胞分泌功能受损, 者相互依存、相 互作用。 2 型糖尿病的治疗应以减轻胰岛素的抵抗和保护胰岛β 细胞为主, 以生活方式干预加 甲双胍作为基础治疗, 根据不同 个体在不同阶段所侧重的不同发病机制, 采用联合、综合管 理。 :2 型糖尿病, 发病机制, 胰岛素抵抗, 药物, 治疗 :R587.1　　:A 　　:1002-0772(2008)2-0010-05 New Strategies for Treatment of Type 2 Diabetes Based on Pathogenesis of the Di sease 　L I U P ei- wen, Y U X ue-f eng .D iv ision of E ndocr ino logy , X inhua Hosp i ta l, Wuhan, H ubei P rov ince 430015, Ch ina Abstract:The pathogenesis of type 2 diabetes is mainly involved in insulin resistan e and impaired insulin se retion by ells, both of whi h intera t w ith ea h others and promote the progress of diabetes.The treatment of type 2 diabetes should fo us on relieving the insulin resistan e and prote ting ell fun tion.Life style intervention plus metformin are essential treatment for type 2 diabetes.Therapeuti options of different treatment are based on different stages of the disease and different path- ogeni fa tors mainly involved in individual diabetes.Rational regimen for diabetes treatment not only in ludes omprehen- sive management of disease itself, but also in ludes management of onditions su h as hypertension and hyperlipidemia. Key Words:type 2 diabetes, pathogenesis, insulin resistan e, medi ations, treatment [ 3-4] 　　, 、 。 [ 5-6] () 。 。 2 , IG T IFG 、 β