_榄香烯联合三苯氧胺抑制乳腺癌MCF_7细胞生长的实验研究_马海琳.pdf

·5 10 · MOD ERN ONCOLO GY, Ap r2008, VO I16, NO 4 的是使用病毒载体 , H iroak i等 [ 6 ] 构建表达针对 survivin mR al in the ab sence of su rvivin [ J ]. Proc N atl A cad Sci U S A , NA 的腺病毒表达载体 p siSu rv (A ) 、p siSu rv (B ) ,转染 H eL a、 2004 , 10 1 (42) : 15100 - 15105. U251、MCF27 等细胞后均显示出近 100%的转染效率和明显 [ 5 ] 　Holen TM , Am arzgu iou iM T, W iiger E, et al. Po sitional effects of 的促进凋亡作用 ,显示出良好的应用前景 。 short interfering RNA s targeting the hum an coagu lation trigger tis sue factor [ J ]. N ucleic A cid s R es, 2002 , 30 ( 8) : 1757 - 1766. 【参考文献 】 [ 6 ] 　H iroak i U , Tosh ih iro T, Katsunori S, et al . A denoviru s m ediated [ 1 ] 　Ambrosin i G, A dida C, A ltieri DC. A novel anti - apop to sis gene, tran sfer of siRNA again st su rvivin induced apop to sis and attenuated su rvivin, exp ressed in cancer and lymphom a [ J ]. N at M ed, 1997 , tumor cell grow th in vitro and in vivo [ J ]. Mol Ther , 2004 , 10 3 ( 8) : 917 - 92 1. ( 1) : 162 - 17 1. [ 2 ] 　沈建军 刘家云 苏明权 ,等. 用 RNA i沉默 su rvivin 基因表达对 [ 7 ] 　Guan HT, Xue XH , D ai ZJ , et al . Down - regu la