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MicroRNA-17–92 Cluster in Exosomes Enhance Neuroplasticity and Functional Recovery After Stroke in Rats by Hongqi Xin, Mark Katakowski, Fengjie Wang, Jian-Yong Qian, Xian Shuang Liu, Meser M. Ali, Benjamin Buller, Zheng Gang Zhang, and Michael Chopp Stroke Volume 48(3):747-753 February 27, 2017 Copyright ? American Heart Association, Inc. All rights reserved. MiR-17–92 cluster elevated multipotent mesenchymal stromal cell (MSC) exosomes augments the improvement of neurological outcome post–middle cerebral artery occlusion (MCAO). Hongqi Xin et al. Stroke. 2017;48:747-753 Copyright ? American Heart Association, Inc. All rights reserved. MiR-17–92 cluster–elevated multipotent mesenchymal stromal cell (MSC) exosomes increase neurite remodeling in the ischemic boundary zone (IBZ). Hongqi Xin et al. Stroke. 2017;48:747-753 Copyright ? American Heart Association, Inc. All rights reserved. MiR-17–92 cluster–elevated multipotent mesenchymal stromal cell (MSC) exosomes increase neuronal dendritic plasticity. Hongqi Xin et al. Stroke. 2017;48:747-753 Copyright ? American Heart Association, Inc. All rights reserved. MiR-17–92 cluster–elevated multipotent mesenchymal stromal cell (MSC) exosomes increase neurogenesis and oligodendrogenesis in the ischemic boundary zone (IBZ). Hongqi Xin et al. Stroke. 2017;48:747-753 Copyright ? American Heart Association, Inc. All rights reserved. MiR-17–92 cluster–elevated multipotent mesenchymal stromal cell (MSC) exosomes negatively regulate the phosphatase and tensin homolog (PTEN) expression and subsequently activate the PI3K/Akt/mTOR signaling pathway. Hongqi Xin et al. Stroke. 2017;48:747-753 Copyright ? American Heart Association, Inc. All rights reserved. MiR-17–92 cluster elevated multipotent mesenchymal stromal cell (MSC) exosomes augments the improvement of neurological outcome post–middle cerebral artery occlusion (MCAO). Modified neurological severity score (mNSS) score (A) and Foot-fault test (B) data show that compared with
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