【生殖医学资料】张云山—新鲜周期或冻融周期移植.pptVIP

对宫外孕发生的影响 有认为IVF鲜周期妊娠的EP风险高于自然妊娠， 部分原因是雌激素对子宫收缩的作用及PE对cilia的影响 超排导致的非（超）生理围植入期环境的影响Effect on implanting embryoextension of the Barker hypothesis 1995年，巴克提出“成人疾病的胎儿起源”假说（Fetal origins of adult disease，FOAD），即著名的“巴克假说”（Barker hypothesis），后发展成“健康和疾病的发育起源（DOHaD）”的理论。 in utero stress may affect childhood development and propensity to adult disease Said another way, health at the time of or even before conception(periconceptional events) may affect in utero and childhood development, predisposition for adult disease. Naturally conceived blastocysts were flushed and transferred to pseudopregnant females after either natural mating (control) or gonadotropin administration and mating (experimental), Pregnant mice were then sacrificed near term (embryonic day 19) and the resultant placentas and fetuses isolated 超排导致的非（超）生理围植入期环境的影响Effect on implanting embryo effect of superovulation on Embryonic Development and Fetal Growth 体外研究：将小鼠胚胎置于育龄期妇女内膜中，并使胚胎暴露于高剂量雌激素环境中，最终导致胚胎发育受损及粘附力下降 超排导致的非（超）生理围植入期环境的影响 Effect on implanting embryo 人体研究：高雌激素水平增加与异常胎盘形成有关的妊娠并发症的风险-除OHSS外还要关注的一个问题 超排导致的非（超）生理围植入期环境的影响 Effect on implanting embryo 超排导致的非（超）生理围植入期环境的影响 Effect on implanting embryo 超排导致的非（超）生理围植入期环境的影响 Effect on implanting embryo 与COS exposure后的鲜周期移植有关的风险包括pre-eclampsia, low birth weight(LBW), small for gestational age (SGA), prematurity, preterm LBW, antepartum hemorrhage, placental abruption, and perinatal death meta-analysis reported that, when compared with fresh-transfer pregnancies, FET pregnancies were associated with significantly reduced risks of preterm birth (RR 0.84), SGA (RR 0.45), LBW (RR 0.69), perinatal mortality(RR 0.68), placental abruption (RR 0.44), and placenta previa (RR 0.71). Risks of very preterm birth, very LBW, congenital anomalies, and neonatal intensive care did not differ significantly. Increased risk of cesarean section delivery was observed with FET (RR 1.10) .FET was associated with reduced risk of preterm birth An Australian registry study compared