aquaporin 1-expressing mcf-7 mammary carcinoma cells show enhanced migration in vitro水通道蛋白1-expressing mcf-7乳房癌的细胞显示增强体外迁移.pdfVIP

J. Biomedical Science and Engineering, 2010, 3, 95-100 JBiSE doi:10.4236/jbise.2010.31014 Published Online January 2010 (http://www.SciRP.org/journal/jbise/). Aquaporin 1-expressing MCF-7 mammary carcinoma cells show enhanced migration in vitro Yong Jiang1,2, Zhi-Bin Jiang3 1Key Laboratory of Industrial Microbiology, Ministry of Education, Tianjin University of Science and Technology, Tianjin, China; 2College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China; 3Jilin Combined Traditional Chinese and Western Medicine Hospital in Jilin Province, Jilin, China. Email: jiangyong@ Received 6 September 2009; revised 19 October 2009; accepted 20 October 2009. ABSTRACT other species have been identified molecularly [2,3]. Aquaporins (AQPs) are membrane water channels that Recent studies have demonstrated that aquaporin play pivotal roles in physiological and pathophysiologi- (AQP) expression facilitates cell migration and pro- cal processes of diverse mammalian organs [4,5,6]. Re- motes angiogenesis and neutrophil motility. Migra- cent studies indicated a novel role of AQPs in cell mi- tion of tumor cells is a crucial step in tumor invasion gration. Mice lacking AQP1, the endothelial water and metastasis. Here we investigated the expression channel, were found to have impaired endothelial cell of AQP in MCF-7 human mammary carcinoma cells migration and tumor angiogenesis [7]. In the same study, and characterized its function in cell migration. Re- over-expression of AQP1 or AQP4 (a structurally related verse Transcript