arterial imaging in digital gangrenes associated with scleroderma-spectrum disorders动脉成像数字坏疽跟scleroderma-spectrum紊乱有关.pdfVIP

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arterial imaging in digital gangrenes associated with scleroderma-spectrum disorders动脉成像数字坏疽跟scleroderma-spectrum紊乱有关.pdf

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arterial imaging in digital gangrenes associated with scleroderma-spectrum disorders动脉成像数字坏疽跟scleroderma-spectrum紊乱有关

Open Journal of Rheumatology and Autoimmune Diseases, 2012, 2, 21-25 21 /10.4236/ojra.2012.22005 Published Online May 2012 (http://www.SciRP.org/journal/ojra) Arterial Imaging in Digital Gangrenes Associated with * Scleroderma-Spectrum Disorders 1 1# 2 1 1 Naoko Nagata , Atsushi Tanemura , Hiroki Higashihara , Yorihisa Kotobuki , Hiroyuki Murota , Mamori Tani1 1 1 , Ken Igawa , Ichiro Katayama 1Department of Dermatology, Osaka University Graduate School of Medicine, Osaka, Japan; 2Department of Radiology, Osaka Uni- versity Graduate School of Medicine, Osaka, Japan. Email: #tanemura@derma.med.osaka-u.ac.jp Received January 10th, 2012; revised February 13th, 2012; accepted February 20th, 2012 ABSTRACT Objectives: Digital refractory gangrene is rarely found in collagen diseases, including systemic sclerosis and is possibly caused by similar underlying vascular damage in peripheral arterial disease (PAD) such as arteriosclerosis obliterans (ASO) and/or thromboangiitis obliterans (TAO) by unclarified mechanisms other than vasculitis and thrombosis. This study evaluated the radiological imaging in patients with digital gangrene associated with collagen disease and com- pared the images with those of PAD based on the results of laboratory and histopathological examinations. Methods: Angiography, MR angiography and/or CT angiography were performed on 6 patients with refractory gangrene or ex- tensive ulcers accompanied by scleroderma-spectrum disorders; 3 with diffuse systemic sclerosis, 1 with limited sys- temic sclerosis, 1 with overlap syndrome and 1 with Sjögren’s syndrome. Results: Although the va