association of superior vena cava syndrome with sleep apnea investigation using an impulse oscillometry system上腔静脉综合症协会与睡眠呼吸暂停调查使用脉冲高频指示系统.pdfVIP
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association of superior vena cava syndrome with sleep apnea investigation using an impulse oscillometry system上腔静脉综合症协会与睡眠呼吸暂停调查使用脉冲高频指示系统
International Journal of Clinical Medicine, 2012, 3, 270-275
/ 10.4236/ijcm.2012.34053 Published Online July 2012 (http://www.SciRP.org/journal/ijcm)
Association of Superior Vena Cava Syndrome with Sleep
Apnea: Investigation Using an Impulse Oscillometry
System
1,2* 1 3 2 2
Masanori Yokoba , Naohito Ishii , Tsuyoshi Ichikawa , Mayuko Wada , Hisashi Mitsufuji ,
Masaru Kubota2 2 1,2
, Noriyuki Masuda , Masato Katagiri
1School of Allied Health Sciences, Kitasato University, Kanagawa, Japan; 2Division of Respiratory Medicine, Kitasato University
Hospital, Kanagawa, Japan; 3Graduate School of Medical Sciences, Kitasato University, Kanagawa, Japan.
*
Email: myoko@kitasato-u.ac.jp
Received March 16th, 2012; revised April 28th, 2012; accepted May 15th, 2012
ABSTRACT
Superior vena cava syndrome (SVCS) patients sometimes show signs of obstructive sleep apnea (OSA). However, the
mechanism causing hypoxia during sleep in SVCS patients is still uncertain. The aim of this study was to elucidate 1)
the changes in central and peripheral respiratory resistance with SVCS; and 2) interpret the mechanism underlying the
development of hypoxia during sleep in patients with SVCS related to OSA. Ten SVCS patients related to a neoplasm
were recruited for this study. The degree of apnea hypopnea index (AHI) for OSA was evaluated by portable diagnosing
device before and after SVCS treatment. We also analyzed the airway resistance and reactance quantitatively in the su-
pine position by Master Screen impulse oscillometry system (MS-IOS®). After SVCS treatment, mean values of AHI
were significantly decreased from 30.9 to 16.9 (/hour) (p = 0.001). Central respiratory resistance (R20) also decreased
significantly from 0.40 to 0.33 kPa/L/s (p = 0.025) in the
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