association of the resistin gene promoter region polymorphism with kawasaki disease in chinese children抵抗素基因启动子区多态性与协会在中国儿童川崎病.pdfVIP

Hindawi Publishing Corporation Mediators of Inflammation Volume 2012, Article ID 356362, 8 pages doi:10.1155/2012/356362 Research Article Association of the Resistin Gene Promoter Region Polymorphism with Kawasaki Disease in Chinese Children Ruixi Liu, Bo He, Fang Gao, Qian Liu, and Qijian Yi Department of Cardiovascular Medicine, Children’s Hospital of Chongqing Medical University and Ministry of Education Key Laboratory of Child Development and Disorders and Key Laboratory of Pediatrics in Chongqing, CSTC2009CA5002, Chongqing International Science and Technology and Cooperation Center for Child Development and Disorders, Yuzhong District, Chongqing 400014, China Correspondence should be addressed to Qijian Yi, boybvip@126.com Received 23 December 2011; Accepted 2 February 2012 Academic Editor: Giamila Fantuzzi Copyright © 2012 Ruixi Liu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Objectives. The −420 C G polymorphism located in the resistin gene (RETN) promoter has recently been suggested to play a potential role in proinflammatory conditions and cardiovascular disease. This study investigated the association of the RETN promoter polymorphism with Kawasaki disease (KD) and its clinical parameters in Chinese children. Methods. We compared patients with complete KD to incomplete KD children. Genotyping of the RETN promoter polymorphism was performed using MassARRAY system, and serum resistin levels were estimated using the sandwich enzyme immunoassay method. Results. There was no significant difference in RETN (−420 C G) genotypes between KD and control groups. However, the frequency of the