are we ready for the use of foxp3+ regulatory t cells for immunodiagnosis and immunotherapy in kidney transplantation我们准备使用foxp3 +调节性t细胞的免疫诊断和免疫治疗肾移植.pdfVIP

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2017-08-27 发布于上海
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are we ready for the use of foxp3+ regulatory t cells for immunodiagnosis and immunotherapy in kidney transplantation我们准备使用foxp3 +调节性t细胞的免疫诊断和免疫治疗肾移植.pdf

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arewereadyfortheuseoffoxp3regulatorytcellsforimmunodiagnosisandimmunotherapyinkidneytransplantation我们准备使用foxp3调节性t细胞的免疫诊断和免疫治疗肾移植

Hindawi Publishing Corporation Journal of Transplantation Volume 2012, Article ID 397952, 15 pages doi:10.1155/2012/397952 Review Article Are We Ready for the Use of Foxp3+ Regulatory T Cells for Immunodiagnosis and Immunotherapy in Kidney Transplantation? Francisco Salcido-Ochoa,1 Nurhashikin Yusof,1 Susan Swee-Shan Hue,2 Doreen Haase,3 Terence Kee,4 and Olaf Rotzschke3 1 Tregs and HLA Research Force, Department of Renal Medicine, Singapore General Hospital, Outram Road, Singapore 169608 2 Tregs and HLA Research Force, Department of Pathology, Singapore General Hospital, Outram Road, Singapore 169608 3 Singapore Immunology Network, 8A Biomedical Grove Level 04-06, Immunos Building, Singapore 138648 4 Department of Renal Medicine, Singapore General Hospital, Outram Road, Singapore 169608 Correspondence should be addressed to Francisco Salcido-Ochoa, francisco.salcido.ochoa@.sg Received 19 January 2012; Accepted 19 March 2012 Academic Editor: Dela Golshayan Copyright © 2012 Francisco Salcido-Ochoa et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The existence of T-cell subsets naturally committed to perform immunoregulation has led to enthusiastic eﬀorts to investigate their role in the immunopathogenesis of transplantation. Being able to modulate alloresponses, regulatory T cells could be used as an immunodiagnostic tool in clinical kidney transplantation. Thus, the measurement of Foxp3 transcripts, the presence of regulatory T cells in kidney biopsies, and the phenotypic characterisation of the T-cell inﬁltrate could aid in the di