arenavirus budding沙粒病毒出芽.pdfVIP

Hindawi Publishing Corporation Advances in Virology Volume 2011, Article ID 180326, 9 pages doi:10.1155/2011/180326 Review Article Arenavirus Budding Shuzo Urata1, 2 and Juan Carlos de la Torre2 1 Department of Emerging Infectious Disease, Institute of Tropical Medicine, Nagasaki University, 1-12-4 Sakamoto, Nagasaki 852-8523, Japan 2 Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA Correspondence should be addressed to Juan Carlos de la Torre, juanct@ Received 19 February 2011; Accepted 23 May 2011 Academic Editor: Fadila Bouamr Copyright © 2011 S. Urata and J. C. de la Torre. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Several arenaviruses cause hemorrhagic fever disease in humans and pose a significant public health concern in their endemic regions. On the other hand, the prototypic arenavirus LCMV is a superb workhorse for the investigation of virus-host interactions and associated disease. The arenavirus small RING finger protein called Z has been shown to be the main driving force of virus budding. The budding activity of Z is mediated by late (L) domain motifs, PT/SAP, and PPXY, located at the C-terminus of Z. This paper will present the current knowledge on arenavirus budding including the diversity of L domain motifs used by different arenaviruses. We will also discuss how improved knowledge of arenavirus budding may facilitate the development of novel antiviral strategies to combat human pathogenic arenaviruses. 1. Introduction Arenaviruses are enveloped viruses with a bisegmented neg-