archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigenarchaeosomes不同脂质成分不同受体介导内吞作用和不同佐剂裹入抗原的免疫反应.pdfVIP

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2017-08-27 发布于上海
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archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigenarchaeosomes不同脂质成分不同受体介导内吞作用和不同佐剂裹入抗原的免疫反应.pdf

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archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigenarchaeosomes不同脂质成分不同受体介导内吞作用和不同佐剂裹入抗原的免疫反应

Archaea 1, 151–164 © 2003 Heron Publishing—Victoria, Canada Archaeosomes varying in lipid composition differ in receptor-mediated endocytosis and differentially adjuvant immune responses to entrapped antigen 1,2 1 1 1 G. DENNIS SPROTT, SUBASH SAD, L. PERRY FLEMING, CHANTAL J. DICAIRE, 1 1 GIRISHCHANDRA B. PATEL and LAKSHMI KRISHNAN 1 Institute for Biological Sciences, National Research Council, 100 Sussex Drive, Ottawa, Ontario, Canada K1A 0R6 2 Author to whom correspondence should be addressed (dennis.sprott@nrc.ca) Received September 11, 2002; accepted December 10, 2002; published online January 31, 2003 Summary Archaeosomes prepared from total polar lipids C -P = caldarchaetidic acid; CTL = cytotoxic T lymphocyte; S extracted from six archaeal species with divergent lipid com- DMPG = dimyristoylphosphatidylglycerol; FBS = fetal bovine se- positions had the capacity to deliver antigen for presentation rum; GM-CSF = granulocyte macrophage colony stimulating factor; IL = interleukin; LPS = lipopolysaccharide; MHC = major histocom- via both MHC class I and class II pathways. Lipid extracts from patibility complex; MTT = dimethylthiazol diphenyltetrazolium bro- Halobacterium halobium and from Halococcus morrhuae – mide; m/z