are oxidized ldlβ2-glycoprotein i complexes pathogenic antigens in autoimmune-mediated atherosclerosis氧化ldlβ2-glycoprotein我在谷动脉粥样硬化复合物致病性抗原.pdfVIP

Clinical Developmental Immunology, June 2004, Vol. 11 (2), pp. 103–111 Are Oxidized LDL/b2-glycoprotein I Complexes Pathogenic Antigens in Autoimmune-mediated Atherosclerosis? EIJI MATSUURAa,* and LUIS R. LOPEZb aDepartment of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; b Corgenix, Inc., Westminster, CO 80234, USA The oxidative modification of low-density lipoprotein (LDL) in the intima of arteries contributes to the initiation and progression of atherosclerotic lesions. We have previously reported that oxidized LDL (oxLDL) interacts with an endogenous plasma protein, b2-glycoprotein I (b2GPI), to form complexes and that the interaction is mediated by oxLDL specific ligands. We have also demonstrated the presence of oxLDL/b2GPI complexes in the blood stream of patients with systemic inflammatory and autoimmune diseases. These findings implicate that oxLDL/b2GPI complexes are possible atherogenic autoantigens. Autoantibodies to oxLDL/b2GPI complexes have been associated with arterial thrombosis. Further, circulating IgG immune complexes containing oxLDL and b2GPI were also detected in patients with systemic lupus erythematosus (SLE) and/or antiphospholipid syndrome (APS). Although many unanswered questions remain about the exact pathogenic mechanism(s) involved, oxLDL/b2GPI complexes may be described as metabolic products relevant in atherogenesis and as significant participants in autoimmune-mediated atherosclerosis. Keywords: Antiphospholipid syndrome; Antipho