are toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromestoll样受体和诱饵受体参与系统性红斑狼疮的免疫发病机理和lupus-like综合症.pdfVIP

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are toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromestoll样受体和诱饵受体参与系统性红斑狼疮的免疫发病机理和lupus-like综合症.pdf

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are toll-like receptors and decoy receptors involved in the immunopathogenesis of systemic lupus erythematosus and lupus-like syndromestoll样受体和诱饵受体参与系统性红斑狼疮的免疫发病机理和lupus-like综合症

Hindawi Publishing Corporation Clinical and Developmental Immunology Volume 2012, Article ID 135932, 5 pages doi:10.1155/2012/135932 Review Article Are Toll-Like Receptors and Decoy Receptors Involved in the Immunopathogenesis of Systemic Lupus Erythematosus and Lupus-Like Syndromes? Giuliana Guggino,1, 2 Anna Rita Giardina,2 Francesco Ciccia,2 Giovanni Triolo,2 Francesco Dieli,1 and Guido Sireci1 1 Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Universita degli Studi di Palermo, DIBIMEF, ` Corso Tukory 211, 90100 Palermo, Italy 2 Divisione di Reumatologia, Dipartimento Biomedico di Medicina Interna e Specialistica, Universita degli Studi di Palermo, ` 90133 Palermo, Italy Correspondence should be addressed to Guido Sireci, guido.sireci@unipa.it Received 30 April 2011; Revised 29 June 2011; Accepted 30 June 2011 Academic Editor: Anisur Rahman Copyright © 2012 Giuliana Guggino et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. In this paper we focus our attention on the role of two families of receptors, Toll-like receptors (TLR) and decoy receptors (DcR) involved in the generation of systemic lupus erythematosus (SLE) and lupus-like syndromes in human and mouse models. To date, these molecules were described in several autoimmune disorders such as rheumatoid arthritis, antiphospholipids syndrome, bowel inﬂammation, and SLE. Here, we summarize the ﬁndings of recent investigations on TLR a