清热解毒软胶囊、维胺酯、安体舒通联用治疗面部寻常痤疮临床疗效观察.doc

清热解毒软胶囊、维胺酯、安体舒通联用治疗面部寻常痤疮临床疗效观察摘要：目的观察清热解毒软胶囊、维胺酯、安体舒通胶囊联用治疗面部寻常痤疮的临床疗效。方法随机将300例寻常痤疮患者分为2组，治疗组250例，口服清热解毒软胶囊、维胺酯和安体舒通。对照组50例，口服阿奇霉素、维胺酯。2组均以10 d为1个疗程，4个疗程后观察疗效。结果治疗组总有效率96.0 %，对照组总有效率74.0 %，2组差异有统计学意义（P＜0.05）。结论清热解毒软胶囊，维胺脂，安体舒通联用治疗面部寻常座疮疗效显著，临床症状改善快。 关键词：痤疮；维胺酯；清热解毒；安体舒通；阿奇霉素 中图分类号：R751、1+2文献标识码：A文章编号：1672-979X(2009)01-0048-02 Clinical Efficacy of Combination of Qingre Jiedu Soft Capsules, Retinamido-ester and Antisterone in Treatment of Facial Acne Vulgaris YAO Xian-ping (Yantai Yuhuangding Hospital, Yantai 264000, China) Abstract：Objective To observe the clinical efficacy of the combination of Qingre Jiedu Soft Capsules(with heat-clearing and detoxicating effect), retinamido-ester and antisterone in the treatment of facial acne vulgaris. Methods Three hundred patients with facial acne vulgaris were randomly divided into two groups of treatment group with the combination of Qingre Jiedu, retinamido-ester and antisterone for 250 cases and control group with the combination of azithromycin and retinamido-ester for 50 cases. For both groups, a course of treatment consisted of 10 days and the clinical efficacy was evaluated after 4 courses of treatment. Results The total effective rate was 96.0 % and 74.0 % for treatment group and control group, respectively. There was a statistical difference in total effective rate in both groups(P＜0.05). Conclusion The clinical efficacy of the combination of Qingre Jiedu, retinamido-ester and antisterone is remarkable in the treatment of facial acne vulgaris with a rapid improvement in clinical symptom. Key words：acne; retinamido-ester; heat-clearing and detoxicating; antisterone; azithromycin 寻常痤疮是青春期常见的毛囊皮脂腺的慢性炎症，与雄激素、皮脂腺和毛囊内微生物密切相关。遗传、饮食、胃肠功能、环境因素、化妆品及精神因素等亦与发病有关。随着生活水平提高，青少年发育年龄提前，痤疮发病年龄也提前到10～15岁。由于环境、饮食、工作生活压力等因素导致病程延长，甚至到35～40岁。单纯中医或西医治疗很难取得理想的效果，且纯中药携带和服用有诸多不便之处。2005～2008年，我们用中成药清热解毒软胶囊，配合维胺酯、安体舒通治寻常痤疮250例，并与口服阿奇霉素、维胺酯治疗50例对照观察，现将结果报告如下。 1资料与方法 1.1一般资料 寻常痤疮皮损患者300例，其中男198例，女102例；年龄15～26岁；病史