automatic estimation of the dynamics of channel conductance using a recurrent neural network自动估计通道电导的动态递归神经网络使用.pdfVIP

Hindawi Publishing Corporation Advances in Artificial Neural Systems Volume 2009, Article ID 724092, 10 pages doi:10.1155/2009/724092 Research Article Automatic Estimation of the Dynamics of Channel Conductance Using a Recurrent Neural Network Masaaki Takahashi and Kiyohisa Natsume Graduate School of Life Science and Systems Engineering, Kyushu Institute of Technology, 2-4 Hibikino, Wakamatsu-ku, Kitakyushu-shi, Fukuoka 808-0196, Japan Correspondence should be addressed to Masaaki Takahashi, takahashi-masaaki@edu.brain.kyutech.ac.jp Received 1 April 2008; Revised 28 June 2008; Accepted 4 October 2008 Recommended by Akira Imada In order to simulate neuronal electrical activities, we must estimate the dynamics of channel conductances from physiological experimental data. However, this approach requires the formulation of differential equations that express the time course of channel conductance. On the other hand, if the dynamics are automatically estimated, neuronal activities can be easily simulated. By using a recurrent neural network (RNN), it is possible to estimate the dynamics of channel conductances without formulating the differential equations. In the present study, we estimated the dynamics of the Na+ and K+ conductances of a squid giant axon using two different fully connected RNNs and were able to reproduce various neuronal activities of the axon. The reproduced activities were an action potential, a threshold, a refractory phenomenon, a rebound action potential, and periodic action potentials with a constant stimulation. RNNs can be trained using channels other than the Na+ and K+ channels. Therefore, using our RNN estimation method, the dynamics of channel conductance can be automatically estimated and the neuronal activities