疏血通注射液治疗原发性肾病综合征临床观察.docVIP

疏血通注射液治疗原发性肾病综合征临床观察摘 要:目的:通过对疏血通注射液(水蛭和地龙提取物)治疗PNS的临床观察,探讨疏血通注射液治疗PNS的临床疗效,为临床治疗PNS提供客观依据。方法:临床纳入脾肾两虚,水湿壅盛兼有瘀血型PNS患者58例,按就诊顺序随机分为治疗组28例,对照组30例。在基础治疗上,治疗组加用疏血通注射液,对照组加用丹参注射液,以2个月为1个疗程,对两组的疗效进行对比观察。结果:(1)治疗组总有效率为82.14%,对照组总有效率为73.33%。治疗组与对照组的中医证候疗效,经统计学比较有显著性差异。(2)治疗组在减少尿蛋白排出量,提高血浆白蛋白水平,降低血脂,改善肾病综合征高凝状态,降低患者的复发率方面均明显优于对照组,两者相比有显著性差异。结论:疏血通注射液配合基础治疗,能明显改善PNS患者临床症状,减少疾病复发。连续用药对白细胞粒细胞,肝功能无影响,值得临床推广使用。 关键词:原发性肾病综合征;疏血通注射液;丹参注射液; 临床研究 中图分类号:R692 文献标识码:B 文章编号:1673-7717(2010)01-0029-03 Clinical Study of the Effect of Primary Nephrotic Syndrome Patients Treated by Shuxuetong Injection SONG Li?qun?1,ZHANG Yi?mo?2 (1.First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,Heilongjiang,China; 2.Qiqihar Hospital of TCM, Qiqihar 161000, Heilongjiang, China) Abstract:Objective:To investigate the clinical effects of Shuxuetong injection (extractive of leech and Lumbricus) on primary nephrotic syndrome (PNS) by the clinical observation of Shuxuetong injection on treating PNS, provide objective evidence for the treatment of PNS.Methods: The 58 spleen and kidney asthenia and retention of water with blood stasis patients were divided into treatment group (n=28) and control group (n=30) by the visit order. Besides of the basic treatments, the treatment group were treated with Shuxuetong injection and the control group were treated with Salvia miltiorrhiza injection.After one course of treatment (2 months),the effects of two groups were compared.Results:(1)The total effective rate of treatment group is 82.14%,the control group is 73.33%. There has significant diference of the Traditional Chinese Medicine manifestations between the two groups.(2)The treatment group is better than the control group on reducing the evacuation of proteinuria, promoting plasma-albumin, degrading blood fat, relieving the blood coagulation tendency, reducing relapse rate. There is difference beteen the two groups.Conclusion:Shuxuetong injection cou