comparative evaluation of permissiveness to dengue virus serotype 2 infection in primary rodent macrophages比较评估的放纵登革2型病毒感染主要啮齿动物巨噬细胞.pdfVIP

Hindawi Publishing Corporation Journal of Tropical Medicine Volume 2012, Article ID 950303, 7 pages doi:10.1155/2012/950303 Research Article Comparative Evaluation of Permissiveness to Dengue Virus Serotype 2 Infection in Primary Rodent Macrophages ´ ´ Jeanette Prada-Arismendy, Veronica Rincon, and Jaime E. Castellanos Instituto de Virologıa, Universidad El Bosque, Carrera 7B Bis No. 132-11, Bogota, Colombia ´ ´ Correspondence should be addressed to Jaime E. Castellanos, castellanosjaime@.co Received 19 October 2011; Accepted 19 December 2011 Academic Editor: Carlos E. P. Corbett Copyright © 2012 Jeanette Prada-Arismendy et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Infection with dengue virus presents a broad clinical spectrum, which can range from asymptomatic cases to severe cases that are characterised by haemorrhagic syndrome and/or shock. The reason for such variability remains unknown. This work evaluated the in vitro permissiveness of mouse, rat, hamster, and guinea pig macrophages to infection by dengue virus 2 (DENV2). The results established that macrophages derived from the BALB/c mouse strain showed higher permissiveness to DENV2 infection than macrophages from other rodent species, although all rodent species studied had the C820T mutation in the oligoadenylate synthetase 1b gene, indicating no relationship to the different in vitro susceptibilities of mouse cells at this locus. Other molecular mechanisms related t