cordyceps sinensis acts as an adenosine a3 receptor agonist on mouse melanoma and lung carcinoma cells, and human fibrosarcoma and colon carcinoma cells冬虫夏草作为腺苷a3受体激动剂对小鼠黑色素瘤和肺癌细胞,和人类纤维肉瘤和结肠癌细胞癌.pdfVIP

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cordyceps sinensis acts as an adenosine a3 receptor agonist on mouse melanoma and lung carcinoma cells, and human fibrosarcoma and colon carcinoma cells冬虫夏草作为腺苷a3受体激动剂对小鼠黑色素瘤和肺癌细胞,和人类纤维肉瘤和结肠癌细胞癌.pdf

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cordyceps sinensis acts as an adenosine a3 receptor agonist on mouse melanoma and lung carcinoma cells, and human fibrosarcoma and colon carcinoma cells冬虫夏草作为腺苷a3受体激动剂对小鼠黑色素瘤和肺癌细胞,和人类纤维肉瘤和结肠癌细胞癌

Pharmacology Pharmacy, 2011, 2, 266-270 doi:10.4236/pp.2011.24034 Published Online October 2011 (http://www.SciRP.org/journal/pp) Cordyceps sinensis Acts as an Adenosine A3 Receptor Agonist on Mouse Melanoma and Lung Carcinoma Cells, and Human Fibrosarcoma and Colon Carcinoma Cells 1 1 1 1 1 Noriko Yoshikawa , Arisa Nishiuchi , Erika Kubo , Yu Yamaguchi , Masaru Kunitomo , Satomi Kagota1 1 1,2 , Kazumasa Shinozuka , Kazuki Nakamura 1Department of Pharmacology, School of Pharmacy and Pharmaceutical Sciences, Mukogawa Women’s University, Nishinomiya, Japan; 2Institute for Biosciences, Mukogawa Women’s University, Nishinomiya, Japan. Email: lfp51193@mukogawa-u.ac.jp Received September 1st, 2011; revised September 25th, 2011; accepted October 15th, 2011. ABSTRACT Cordyceps sinensis, a parasitic fungus on the larva of Lapidoptera, has been used as a traditional Chinese medicine. We previously reported that the growth of B16-BL6 mouse melanoma (B 16-BL6) cells and mouse Lewis lung carcinoma (LLC) cells was inhibited by cordycepin (3’-deoxyadenosine), an ingredient of Cordyceps sinensis, and its effect was antagonized by MRS 1191, a selective adenosine A receptor (A -R) antagonist although adenosine (up to 100 μM) had 3 3 no effect on the growth of B 16-BL6 and LLC cells. In this study, we investigated whether water extracts of Cordyceps sinensis (WECS) inhibit the growth of B 16-BL6 cells, LLC cells, HT 1080 human fibrosarcoma (HT 1080) cells and CW-2 human colon carcinoma (CW-2) cells via their A3-R. As a result, the growth of all cell lines were potently inhib- ited by WECS (10 μg/mL) and the inhibitory effect of WECS was significantly antagonized by MRS 119