establishment and molecular characterization of breast cancer mesenchymal stem cell line derived from human non-metastasis breast cancer tumor建立和乳腺癌的分子鉴定间充质干细胞系源自人类non-metastasis乳腺癌肿瘤.pdfVIP

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establishment and molecular characterization of breast cancer mesenchymal stem cell line derived from human non-metastasis breast cancer tumor建立和乳腺癌的分子鉴定间充质干细胞系源自人类non-metastasis乳腺癌肿瘤.pdf

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establishment and molecular characterization of breast cancer mesenchymal stem cell line derived from human non-metastasis breast cancer tumor建立和乳腺癌的分子鉴定间充质干细胞系源自人类non-metastasis乳腺癌肿瘤

Vol.1, No.2, 21-28 (2011) Stem Cell Discovery doi:10.4236/scd.2011.12003 Establishment and molecular characterization of breast cancer mesenchymal stem cell line derived from human non-metastasis breast cancer tumor Pravin Potdar, Sachin Chaugule Department of Molecular Medicine and Biology, Jaslok Hospital and Research Centre, Mumbai, India; Corresponding Author: ppotdar@ th rd st Received April 29 , 2011; revised May 23 , 2011; accepted May 31 , 2011. ABSTRACT the neoplastic clone. It is less clear from most of the breast cancers studies that which cells within the tumor Breast cancer remains a leading cause of mor- clone possess tumor-initiating cell function for main- bidity and mortality in women mainly because of taining tumor growth. The identification of potential the propensity of primary breast tumors to me- breast cancer stem cells is the most important task for tastasize. It is composed of heterogeneous cell the study due to the characteristics of these stem cells populations with different biological properties. which are resistant to conventional cancer therapy [1]. Breast cancer-initiating cells have been recently + −/low Pardal et