a fork in the path developing therapeutic inroads with foxo proteins叉子的路径发展同foxo蛋白质治疗进展.pdfVIP

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a fork in the path developing therapeutic inroads with foxo proteins叉子的路径发展同foxo蛋白质治疗进展.pdf

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a fork in the path developing therapeutic inroads with foxo proteins叉子的路径发展同foxo蛋白质治疗进展

[Oxidative Medicine and Cellular Longevity 2:3, 119-129; July/August 2009]; ©2009 Landes Bioscience Review A fork in the path Developing therapeutic inroads with FoxO proteins 1-5, 1 1 1 Kenneth Maiese, * Jinling Hou, Zhao Zhong Chong and Yan Chen Shang 1Division of Cellular and Molecular Cerebral Ischemia; 2Departments of Neurology and Anatomy Cell Biology; 3Barbara Ann Karmanos Cancer Institute; 4Center for Molecular Medicine and Genetics; 5Institute of Environmental Health Sciences; Wayne State University School of Medicine; Detroit, MI USA Key words: aging, angiogenesis, apoptosis, cancer, diabetes, immune system, ischemia, neurodegeneration, oxidative stress, stem cells Advances in clinical care for disorders involving any system play a significant role in cognitive function and emotion, such of the body necessitates novel therapeutic strategies that can as the hippocampus, the amygdala and the nucleus accumbens.4 focus upon the modulation of cellular proliferation, metabolism, In contrast, FoxO1 may be more suited for the control of motor inflammation and longevity. In this respect, members of the function and memory formation, since the expression of this mammalian forkhead transcription factors of the O class (FoxOs) protein is primarily in the striatum and sub-regions of the that include FoxO1, FoxO3, FoxO4 and FoxO6 are increasingly hippocampus.4 In addition, FoxO3 is more diffusely represented being recognized as exciting prospects for multiple disorders. in the hippocampus, cortex and cerebellum, suggesting a comple- These transcription factors govern development, proliferation, mentary