a perfusion mri study of emotional valence and arousal in parkinson’s disease灌注磁共振成像研究帕金森病的情感价和兴奋.pdfVIP

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a perfusion mri study of emotional valence and arousal in parkinson’s disease灌注磁共振成像研究帕金森病的情感价和兴奋.pdf

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a perfusion mri study of emotional valence and arousal in parkinson’s disease灌注磁共振成像研究帕金森病的情感价和兴奋

SAGE-Hindawi Access to Research Parkinson’s Disease Volume 2011, Article ID 742907, 10 pages doi:10.4061/2011/742907 Research Article A Perfusion MRI Study of Emotional Valence and Arousal in Parkinson’s Disease Sunsern Limsoontarakul,1, 2 Meghan C. Campbell,3 and Kevin J. Black1, 3, 4, 5 1 Department of Psychiatry, Washington University School of Medicine St. Louis, St. Louis, MO 63110, USA 2 Department of Neurology, University of British Columbia, Vancouver, BC, Canada V6T 2B5 3 Department of Neurology, Washington University School of Medicine St. Louis, St. Louis, MO 63110, USA 4 Department of Radiology, Washington University School of Medicine St. Louis, St. Louis, MO 63110, USA 5 Department of Anatomy Neurobiology, Washington University School of Medicine St. Louis, St. Louis, MO 63110, USA Correspondence should be addressed to Kevin J. Black, kevin@ Received 10 November 2010; Revised 27 July 2011; Accepted 29 July 2011 Academic Editor: Antonio Strafella Copyright © 2011 Sunsern Limsoontarakul et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Background. Brain regions subserving emotion have mostly been studied using functional magnetic resonance imaging (fMRI) during emotion provocation procedures in healthy participants. Objective. To identify neuroanatomical regions associated with spontaneous changes in emotional state over time. Methods. Self-rated emotional valence and arousal scores, and regional cerebral blood ﬂow (rCBF) measured by perfusion MRI, were measured 4 or 8 times spanning at least 2 weeks in each of 21 subjects with Parkinson’s di