antiatherogenic and anti-ischemic properties of traditional chinese medicine xinkeshu via endothelial protecting functionantiatherogenic中医和anti-ischemic属性xinkeshu通过内皮保护作用.pdfVIP

Hindawi Publishing Corporation Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 302137, 9 pages doi:10.1155/2012/302137 Research Article Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function Xu Tao,1, 2 Peng Jing-bo,1 Zhang Wen-tong,1, 3 Zhao Xin,1 Zhang Tao-tao,1 Yang Shi-jun,1 Fang Lei,1 Zou Zhong-mei,1 and Cai Da-yong1 1 Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100193, China 2 Neurology Department, China Meitan General Hospital, Beijing 100028, China 3 Neurology Department, Beijing Huimin Hospital, Beijing 100054, China Correspondence should be addressed to Cai Da-yong, beijingcdy@ Received 1 April 2011; Accepted 8 August 2011 Academic Editor: E. Yesilada Copyright © 2012 Xu Tao et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Including herbal medicine, complementary and alternative medicine (CAM) is popular worldwide. The traditional Chinese med- icine xinkeshu has been widely used to treat coronary heart disease in China. This study was designed to investigate the protective effect and probable mechanism of xinkeshu tablet to atherosclerotic myocardial ischemia rabbit. Rabbits were divided into four groups (n = 12 each) and fed with different diet for 12 weeks: Control (standard diet), Model (high-cholesterol diet), XKS (high- cholesterol diet with 184.8 mg/kg/d xinkeshu), and Atorvastatin (high-cholesterol diet with 5.0 mg/kg/d atorvastatin). Plasma lipo- protein, ECG, endothelium-dependent vessel relaxation, hi