catheter with dielectric optical filter deposited upon the fiber optic end for raman in vivo biospectroscopy applications导管与介质滤光片沉积在光纤喇曼体内biospectroscopy应用程序结束.pdfVIP

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catheter with dielectric optical filter deposited upon the fiber optic end for raman in vivo biospectroscopy applications导管与介质滤光片沉积在光纤喇曼体内biospectroscopy应用程序结束.pdf

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catheter with dielectric optical filter deposited upon the fiber optic end for raman in vivo biospectroscopy applications导管与介质滤光片沉积在光纤喇曼体内biospectroscopy应用程序结束

Spectroscopy 22 (2008) 459–466 459 DOI 10.3233/SPE-2008-0364 IOS Press Catheter with dielectric optical ﬁlter deposited upon the ﬁber optic end for Raman in vivo biospectroscopy applications Carlos José de Lima a , Marcos Tadeu T. Pacheco a , Antonio Balbin Villaverde a , Renato Amaro Zângaro a , Leonardo Marmo Moreira a,∗ and Álvaro José Damião b a Laboratório de Instrumentação Optobiomédica, Instituto de Pesquisa e Desenvolvimento (IPD), Universidade do Vale do Paraíba (UNIVAP), Urbanova CEP 12244-000, São José dos Campos, SP, Brazil b Laboratório de Medição de Superfícies Ópticas – LMSO, IEAv, CTA, Bairro Putim CEP 12228-840, São José dos Campos, SP, Brazil Abstract. Raman spectroscopy (RS) is a powerful tool that allows obtaining signiﬁcant biochemical information from biologi- cal tissue. The ﬁber optic catheter permits applications in vivo that present wide clinical employment. This biochemical analysis is developed through a guide light that furnishes to Raman spectroscopy system the data obtained from tissue. These Raman signals represent the modes of vibration of molecular groups that are present in the biological molecules. Raman measurements undergo the optical inﬂuence of the material that constitutes the catheter, mainly Raman scattering of the silica that composes the ﬁber optic, decreasing signal to noise ratio (SNR) of the resultant spectra. In this work, a dielectric optical ﬁlter called “bandpass” was deposited upon the surface of the tip of the central ﬁber optic (distal probe). Indeed, other six ﬁbers without any optical ﬁlter are disposed around this central optical ﬁber with “bandpass”. This prototype of catheter presented signiﬁ- cant decrease of the silica Raman scattering when compared with unﬁltered catheters. The biomedical applications of this new catheter are auspicious, involving biochemical analysis and diagnosis in viv