risk stratification treatment of pediatric rhabdomyosarcoma south egypt cancer institute experience危险分层治疗儿童横纹肌肉瘤南埃及癌症研究所的经验.pdf

Journal of Cancer Therapy, 2012, 3, 595-601 1 /10.4236/jct.2012.35076 Published Online October 2012 (http://www.SciRP.org/journal/jct) Risk Stratification Treatment of Pediatric Rhabdomyosarcoma: South Egypt Cancer Institute Experience 1* 2 2 3 4 Hamza Abbas , Amany M. Ali , Heba Abdel Razik Sayed , Mohamed A. Salem , Mohammed Hamdy 1The Radiation Oncology Department, South Egypt Cancer Institute, Assiut University, Cairo, Egypt; 2Pediatric Oncology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt; 3Department of Surgical Oncology, South Egypt Cancer Institute, Assiut University, Assiut, Egypt; 4Diagnostic Radiology Department, South Egypt Cancer Institute, Assiut University, Assiut, Egypt. * Email: hamza_assiut@ Received July 27th, 2012; revised August 29th, 2012; accepted September 10th, 2012 ABSTRACT Risk stratification allows tailoring of treatment protocol using, for selected patients, reduced total chemotherapy expo- sure, including decreases in alkylator therapy and avoidance of agents with recognized risk of late complications (an- thracyclines), elimination of irradiation and reduction of radiotherapy dose. Patients and Methods: Twenty-nine newly diagnosed pediatric rhabdomyosarcoma patients attended the pediatric oncology department between January 2008 and May 2011. Patients were divided into 3 groups according to age, stage, group, pathology and site of the tumor. Treatment protocol tailored according to risk group. Results: Twenty-nine newly diagnosed pediatric rhabdomyo- sarcoma patients were evaluated. Seven patients had low risk, Intermediate ris