role of brush biopsy and dna cytometry for prevention, diagnosis, therapy, and followup care of oral cancer刷的活检和dna血细胞计数预防、诊断、治疗和后续照顾口腔癌.pdf

Hindawi Publishing Corporation Journal of Oncology Volume 2011, Article ID 875959, 7 pages doi:10.1155/2011/875959 Review Article Role of Brush Biopsy and DNA Cytometry for Prevention, Diagnosis, Therapy, and Followup Care of Oral Cancer ¨ 1 2 ¨ 3 2 Alfred Bocking, Christoph Sproll, Nikolas Stocklein, Christian Naujoks, 2 ¨ 2 ¨ 2 Rita Depprich, Norbert R. Kubler, and Jorg Handschel 1 Institute of Cytopathology, Heinrich-Heine-University, Moorenstraβe 5, 40225 D¨usseldorf, Germany 2 Department for Cranio- and Maxillofacial Surgery, Heinrich-Heine-University, Moorenstraβe 5, 40225 D¨usseldorf, Germany 3 Department of General, Visceral, and Pediatric Surgery, University Hospital D¨usseldorf, Heinrich-Heine-University, 40225 D¨usseldorf, Germany ¨ Correspondence should be addressed to Alfred Bocking, alfred.boecking@uni-duesseldorf.de Received 30 September 2010; Accepted 21 November 2010 Academic Editor: Pankaj Chaturvedi ¨ Copyright © 2011 Alfred Bocking et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Late diagnosis resulting in late treatment and locoregional failure after surgery are the main causes of death in patients with oral squamous cell carcinomas (SCCs). Actually, exfoliative cytology is increasingly used for early detection of oral cancer and has been the s