role of endothelium on the abnormal angiotensin-mediated vascular functions in epileptic rats作用的内皮异常angiotensin-mediated在癫痫大鼠血管功能.pdf

Vol.3, No.2, 174-182 (2012) Journal of Biophysical Chemistry /10.4236/jbpc.2012.32019 Role of endothelium on the abnormal Angiotensin-mediated vascular functions in epileptic rats 1* 2 2 2 Carolina Restini , Rosana Reis , Claudio Costa-Neto , Norberto Garcia-Cairasco , José Cortes-de-Oliveira2, Lusiane Bendhack3 1Universidade de Ribeirão Preto—UNAERP. Curso de Medicina, Ribeirāo Preto, Brasil; * Corresponding Author: carolbaraldi@ 2Faculdade de Medicina de Ribeirão Preto-USP, Ribeirão Preto, Brasil 3Faculdade de Ciências Farmacêuticas de Ribeirão Preto-USP, Ribeirão Preto, Brasil Received 28 January 2012; revised 20 February 2012; accepted 14 March 2012 ABSTRACT pression was higher in both E+ WAR and Wistar, but it was lower in both E– WAR and Wistar. Epidemiological studies have found that the risk Endothelium impairs the contractile response for cardiovascular disease is increased in patients induced by Angiotensin in WAR, suggesting that with epilepsy. The Renin Angiontensin System endothelial relaxing factors play important role (RAS), an important player in vascular tone control, on the aorta contraction. is also involved in many neurological disorders, including seizures and epilepsy. Although it has Keywords: Endothelium; Aorta Myogenic Tone; been reported that Angiotensin II (Ang II) release Angiotensin; Angiotensin II Receptor; Epilepsy and Angiotensin receptors expression are altered in many cerebral areas in patients/animal models