role of structure-based changes due to somatic mutation in highly homologous dna-binding and dna-hydrolyzing autoantibodies exemplified by a23p substitution in the vh domain作用,基于结构的变化由于高度同源的体细胞突变dna结合蛋白和dna-hydrolyzing自身抗体以a23p vh域替换.pdfVIP

Hindawi Publishing Corporation Autoimmune Diseases Volume 2012, Article ID 683829, 7 pages doi:10.1155/2012/683829 Research Article Role of Structure-Based Changes due to Somatic Mutation in Highly Homologous DNA-Binding and DNA-Hydrolyzing Autoantibodies Exemplified by A23P Substitution in the VH Domain A. V. Kozyr,1 A. V. Kolesnikov,1, 2 A. E. Khlyntseva,1 A. G. Bogun,1 G. A. Savchenko,1 I. G. Shemyakin,1 and A. G. Gabibov3 1 State Research Center for Applied Microbiology and Biotechnology, Serpuhov District Obolensk 142279, Russia 2 Ins