原创力文档signal transduction pathways in mast cell granule-mediated endothelial cell activation在肥大细胞信号转导途径granule-mediated内皮细胞激活.pdfVIP
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signal transduction pathways in mast cell granule-mediated endothelial cell activation在肥大细胞信号转导途径granule-mediated内皮细胞激活
Research Communication
Mediators of Inflammation, 12(2), 79/87 (April 2003)
BACKGROUND : We have previously shown that incuba- Signal transduction pathways in
tion of human endothelial cells with mast cell
granules results in potentiation of lipopolysacchar- mast cell granule-mediated
ide-induced production of interleukin-6 and interleu- endothelial cell activation
kin-8.
Aims : The objective of the present study was to
identify candidate molecules and signal transduction
pathways involved in the synergy between mast cell 1 2 2
Luqi Chi , Lisa Stehno-Bittel , Irina Smirnova ,
granules and lipopolysaccharide on endothelial cell Daniel J Stechschulte1 and
activation. CA,1
Methods : Human umbilical vein endothelial cells Kottarappat N. Dileepan
were incubated with rat mast cell granules in the
presence and absence of lipopolysaccharide, and IL-6
production was quantified. The status of c-Jun amino- 1Division of Allergy, Clinical Immunology and
terminal kinase and extracellular signal-regulated Rheumatology, Department of Medicine, and
kinase 1/2 activation, nuclear factor-kB translocation 2Department of Physical Therapy and Rehabilitation
and intracellular calcium levels were determined to
Sciences, University of Kansas Medical Center, 3901
identify the mechanism of synergy between mast cell
Rainbow Boulevard, Kansas City, KS 66160-7317, USA
granules and lipopolysaccaride.
Results : Mast cell granu
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