stability analysis of a model for foreign body fibrotic reactions模型的稳定性分析异物纤维化反应.pdf

Hindawi Publishing Corporation Computational and Mathematical Methods in Medicine Volume 2012, Article ID 809864, 11 pages doi:10.1155/2012/809864 Research Article Stability Analysis of a Model for Foreign Body Fibrotic Reactions A. Ibraguimov,1 L. Owens,2 J. Su,2 and L. Tang3 1 Department of Mathematics and Statistics, Texas Tech University, P.O. Box 41042, Lubbock, TX 79409-1042, USA 2 Department of Mathematics, The University of Texas at Arlington, Arlington, TX 76019, USA 3 Department of Bioengineering, The University of Texas at Arlington, Arlington, TX 76019, USA Correspondence should be addressed to A. Ibraguimov, akif.ibraguimov@ Received 30 April 2012; Revised 1 August 2012; Accepted 6 August 2012 Academic Editor: Gary C. An Copyright © 2012 A. Ibraguimov et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Implanted medical devices often trigger immunological and inflammatory reactions from surrounding tissues. The foreign body- mediated tissue responses may result in varying degrees of fibrotic tissue formation. There is an intensive research interest in the area of wound healing modeling, and quantitative methods are proposed to systematically study the behavior of this complex system of multiple cells, proteins, and enzymes. This paper introduces a kinetics-based model for analyzing reactions of various cells/proteins and biochemical processes as well as their transient behavior during the implant healing in 2-dimensional space. In particular, we provide a detailed modeling study of different roles of macrophages (M Φ) and their effects on fibrotic reactions. The main mathematical result indicates